Skopouli F N, Talal A, Galanopoulou V, Tsampoulas C G, Drosos A A, Moutsopoulos H M
Department of Internal Medicine, School of Medicine, Ioannina, Greece.
J Rheumatol. 1990 May;17(5):618-20.
Our study describes the prevalence, clinical picture, course and sequelae of Raynaud's phenomenon in patients with primary Sjögren's syndrome. Furthermore, our study compares the clinical, serologic and immunogenetic profile of patients with Raynaud's phenomenon versus those without Raynaud's phenomenon. It seems that Raynaud's phenomenon is a common manifestation (33%) in patients with primary Sjögren's syndrome, precedes sicca manifestations in 42% of patients and follows a pleomorphic course; in some patients (14%) it disappears during the course of Sjögren's syndrome, in others (30%) the frequency of attacks decreases while in a 3rd group (56%) it remains the same. The local clinical sequelae of Raynaud's phenomenon in patients with primary Sjögren's syndrome are swollen hands and evidence of small, soft tissue calcifications on radiographs. Digital pulp ulcers, sclerodactyly or periungal telengiectases are not seen. It seems however, that patients with primary Sjögren's syndrome and Raynaud's phenomenon develop glomerulonephritis, myositis and peripheral neuropathy more often than patients without Raynaud's phenomenon. These differences however, had no statistical significance. Finally, the autoantibody profile is similar in patients with and without Raynaud's phenomenon, while patients without Raynaud's phenomenon and primary Sjögren's syndrome showed a negative but not statistically significant association with the HLA-DR4 alloantigen.
我们的研究描述了原发性干燥综合征患者雷诺现象的患病率、临床表现、病程及后遗症。此外，我们的研究比较了有雷诺现象与无雷诺现象的原发性干燥综合征患者的临床、血清学及免疫遗传学特征。雷诺现象似乎是原发性干燥综合征患者的常见表现（33%），在42%的患者中先于干燥表现出现，且病程呈多形性；部分患者（14%）在干燥综合征病程中雷诺现象消失，部分患者（30%）发作频率降低，另一组患者（56%）发作频率不变。原发性干燥综合征患者雷诺现象的局部临床后遗症为手部肿胀，X线片显示有小的软组织钙化。未发现指腹溃疡、指硬化或甲周毛细血管扩张。然而，原发性干燥综合征合并雷诺现象的患者似乎比无雷诺现象的患者更易发生肾小球肾炎、肌炎及周围神经病变。不过，这些差异无统计学意义。最后，有与无雷诺现象患者的自身抗体谱相似，而无雷诺现象的原发性干燥综合征患者与HLA - DR4同种抗原呈阴性但无统计学意义的关联。
