Clarke Loren E, Conway Andrea B, Warner Nicole M, Barnwell Patricia N, Sceppa Jennifer, Helm Klaus F
Department of Pathology, The Penn State Hershey Medical Center, Hershey, PA 17033, USA.
J Cutan Pathol. 2013 Jul;40(7):646-50. doi: 10.1111/cup.12135. Epub 2013 Apr 17.
Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs.
We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD.
We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4.
We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.
细胞角蛋白7（CK7）和Cam 5.2常用于鉴别乳腺外佩吉特病（EPD）和原位鳞状细胞癌（SCC），因为一般认为它们在前一种疾病中表达，而在后一种疾病中不表达。然而，我们遇到了CK7阳性和Cam 5.2阳性的SCC。
我们评估了SCC和EPD中CK7、Cam 5.2和Ber-Ep4的表达。
我们发现SCC中CK7和Cam 5.2呈显著阳性，特别是那些具有佩吉特样模式的病例。只有1例表达Ber-Ep4。
我们得出结论，SCC中可能出现CK7和Cam 5.2表达。建议使用包括Ber-Ep4在内的一组抗体进行免疫组织化学鉴别EPD和SCC。
