Orth Patrick, Anagnostakos Konstantinos
Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Saar, Germany.
Orthopedics. 2013 Apr;36(4):290-300. doi: 10.3928/01477447-20130327-08.
The aim of this review was to provide information about the variety of thrombophilic and hypofibrinolytic markers that are possible risk factors for the development of osteonecrosis and bone marrow edema syndrome. A total of 48 parameters were identified in 45 studies that included 2163 patients. The most frequently reported laboratory findings included altered serum concentrations of lipoproteins, decreased concentration and function of fibrinolytic agents, increased levels of thrombophilic markers, and several single nucleotide polymorphisms. Despite inhomogeneities in reported parameters, results, patients' collectives, and treatment strategies, these data suggest that coagulation abnormalities may play an important role in the emergence of osteonecrosis and bone marrow edema syndrome.
本综述的目的是提供有关多种血栓形成倾向和低纤溶标记物的信息，这些标记物可能是骨坏死和骨髓水肿综合征发生的危险因素。在45项研究中总共确定了48个参数，这些研究纳入了2163例患者。最常报告的实验室检查结果包括血清脂蛋白浓度改变、纤溶因子浓度和功能降低、血栓形成倾向标记物水平升高以及几种单核苷酸多态性。尽管所报告的参数、结果、患者群体和治疗策略存在异质性，但这些数据表明凝血异常可能在骨坏死和骨髓水肿综合征的发生中起重要作用。
