Division of Hematology and Oncology, Private Practice Baltimore Maryland, MD, USA.
Best Pract Res Clin Anaesthesiol. 2013 Mar;27(1):131-40. doi: 10.1016/j.bpa.2012.12.001.
Conditions known as iron-deficiency syndromes are very common in various patient populations, and they can adversely affect the outcomes of the patients, in addition to increasing their risk of getting transfused. Iron-deficiency syndromes include absolute iron deficiency (absence of storage iron), functional iron deficiency (when demand for iron exceeds the supply in face of intense stimulation erythropoiesis) and iron sequestration (in which existing storage iron becomes unavailable); these conditions often co-exist in hospitalised patients, making the diagnosis and management more difficult. Nonetheless, iron is emerging as a safe and effective therapy in patients suffering from these conditions. Notably, several intravenous iron formulations are available and they can be used safely and effectively to restore the body iron levels (possibly even in a single treatment episode). Data from ongoing clinical trials are expected to further establish the role of these products in treatment of patients with anaemia.
缺铁综合征在各种患者群体中非常常见，除了增加输血风险外，还会对患者的预后产生不利影响。缺铁综合征包括绝对缺铁（无储存铁）、功能性缺铁（当铁需求超过供应时，面对强烈的刺激红细胞生成）和铁螯合（其中现有的储存铁变得无法获得）；这些情况经常同时存在于住院患者中，使诊断和管理更加困难。然而，铁已成为患有这些病症的患者的一种安全有效的治疗方法。值得注意的是，有几种静脉内铁制剂可供使用，它们可以安全有效地用于恢复体内铁水平（甚至可能在单次治疗中）。正在进行的临床试验数据有望进一步确定这些产品在治疗贫血患者中的作用。
