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蓖麻毒素中毒后血清和尿液中蓖麻毒素的连续水平。

Serial ricinine levels in serum and urine after ricin intoxication.

机构信息

Norwegian Defence Research Establishment (FFI), P.O. Box 25, N-2027 Kjeller, Norway.

出版信息

J Anal Toxicol. 2013 Jun;37(5):313-7. doi: 10.1093/jat/bkt026. Epub 2013 Apr 16.

Abstract

Ricinine is an alkaloid present in the castor bean plant (Ricinus communis) that can be used as a biomarker for ricin poisoning. Serial ricinine levels are reported in the serum and urine of a patient suffering from intentional ricin intoxication. The patient was brought to the hospital 4 h after injection and oral intake of a castor bean extract, but died 38 h later, despite intensive medical care. Ricinine was isolated from the samples by solid-phase extraction and quantitatively determined by isotopic dilution liquid chromatography-mass spectrometry. The ricinine level in serum declined from 33 to 23 ng/mL between 10 and 29 h post-exposure. Three urine samples collected from 12 to 41 h after ricin intoxication showed ricinine concentrations in the range of 20-58 ng/mL. The creatinine corrected values (21-30 µg/g) indicated a concentration-time profile with a maximum ricinine level in urine between 12 and 29 h after exposure.

摘要

黎豆碱是存在于蓖麻植物(Ricinus communis)中的一种生物碱,可作为蓖麻毒素中毒的生物标志物。有报告称,在一名因蓄意摄入蓖麻毒素而中毒的患者的血清和尿液中存在连续的黎豆碱水平。该患者在注射和口服蓖麻提取物后 4 小时被送往医院,但在 38 小时后死亡,尽管进行了强化医疗护理。通过固相萃取从样品中分离出黎豆碱,并通过同位素稀释液相色谱-质谱法对其进行定量测定。暴露后 10 至 29 小时,血清中的黎豆碱水平从 33 降至 23 ng/mL。在蓖麻毒素中毒后 12 至 41 小时采集的 3 个尿液样本中,黎豆碱浓度范围为 20-58 ng/mL。肌酐校正值(21-30 µg/g)表明,尿液中黎豆碱的浓度-时间曲线在暴露后 12 至 29 小时之间达到最大值。

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