血管紧张素转换酶抑制剂联合维拉帕米治疗对2型糖尿病高血压患者循环抵抗素水平的有益影响。
Beneficial effect of combination therapy using an angiotensin-converting enzyme inhibitor plus verapamil on circulating resistin levels in hypertensive patients with type 2 diabetes.
作者信息
Rubio-Guerra Alberto F, Vargas-Robles Hilda, Lozano Nuevo Jose J, Elizalde-Barrera Cesar I, Huerta-Ramirez Saul, Escalante-Acosta Bruno A
机构信息
Hypertension Clinic, Hospital General de Ticomán SS DF, Mexican Group For Basic And Clinical Research In Internal Medicine, AC;
出版信息
Exp Clin Cardiol. 2012 Winter;17(4):202-4.
BACKGROUND
Resistin levels are strongly correlated with insulin resistance and vascular inflammation. Type 2 diabetic and hypertensive patients have higher circulating levels of resistin, which is associated with endothelial dysfunction.
OBJECTIVE
To compare the effect of trandolapril (T) and its fixed-dose combination with verapamil (FDTV) on resistin levels in hypertensive, type-2 diabetic patients.
METHODS
Forty type-2 diabetic patients with never-treated hypertension were randomly assigned to two groups. One group received FDTV 2 mg/180 mg once per day; the other group received T 2 mg once per day. Study drugs were administered for three months in both groups. Resistin levels were measured using ELISA at the beginning of the study and at study end. Patients were evaluated monthly for blood pressure, fasting serum glucose levels and adverse events. Statistical analysis was performed using ANOVA.
RESULTS
All patients experienced a significant reduction in blood pressure. Both therapeutic regimens reduced resistin levels; however, FDTV treatment resulted in a greater decrease in resistin levels (mean [± SD] 25.5±13 ng/mL to 17.2±10 ng/mL) when compared with T treatment (22.4±12 ng/mL to 18.5±8 ng/mL) (P<0.05). None of the patients experienced an adverse event.
CONCLUSION
Results showed that FDTV resulted in a greater reduction in resistin levels than T treatment alone.
背景
抵抗素水平与胰岛素抵抗和血管炎症密切相关。2型糖尿病和高血压患者的循环抵抗素水平较高，这与内皮功能障碍有关。
目的
比较trandolapril（T）及其与维拉帕米的固定剂量组合（FDTV）对高血压2型糖尿病患者抵抗素水平的影响。
方法
40例未经治疗的高血压2型糖尿病患者随机分为两组。一组每天服用一次2 mg/180 mg的FDTV；另一组每天服用一次2 mg的T。两组均给予研究药物三个月。在研究开始时和研究结束时使用ELISA测量抵抗素水平。每月对患者进行血压、空腹血糖水平和不良事件评估。使用方差分析进行统计分析。
结果
所有患者的血压均显著降低。两种治疗方案均降低了抵抗素水平；然而，与T治疗（22.4±12 ng/mL至18.5±8 ng/mL）相比，FDTV治疗导致抵抗素水平下降幅度更大（平均[±标准差]从25.5±13 ng/mL降至17.2±10 ng/mL）（P<0.05）。所有患者均未发生不良事件。
结论
结果表明，与单独使用T治疗相比，FDTV可使抵抗素水平降低幅度更大。
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