Hypertension Clinic, Hospital General de Ticomán SS D.F., México D.F., Mexico.
Kidney Blood Press Res. 2009;32(2):106-9. doi: 10.1159/000210554. Epub 2009 Apr 3.
BACKGROUND/AIMS: Endothelial dysfunction, a common feature among hypertensive and type-2 diabetic patients, is associated with inflammation, increased levels of circulating soluble adhesion molecules (SAM), and urinary albumin excretion. The aim of this study was to evaluate the role of circulating SAM levels in the development of albuminuria in hypertensive type-2 diabetic patients.
We studied 30 hypertensive type-2 diabetic patients and 30 non-diabetic normotensive subjects, and measured their VCAM-1, ICAM-1 and E-selectin levels by ELISA, and their 24-hour urinary albumin excretion by nephelometry; the levels of circulating adhesion molecules and albuminuria were correlated with the Spearman correlation coefficient.
We found that the diabetic patients had significantly (p < 0.001) higher levels of circulating SAM than control subjects. When levels of circulating SAM were correlated with albuminuria, we found a significant correlation between VCAM-1 levels and 24-hour urinary albumin excretion (r = 0.4, p < 0.02).
Our results suggest that VCAM-1 may be a marker of nephropathy in hypertensive type-2 diabetic patients.
背景/目的：内皮功能障碍是高血压和 2 型糖尿病患者的共同特征，与炎症、循环可溶性黏附分子（SAM）水平升高和尿白蛋白排泄增加有关。本研究旨在评估循环 SAM 水平在高血压 2 型糖尿病患者白蛋白尿发展中的作用。
我们研究了 30 例高血压 2 型糖尿病患者和 30 例非糖尿病血压正常的受试者，并通过 ELISA 测定其 VCAM-1、ICAM-1 和 E-选择素水平，通过散射比浊法测定其 24 小时尿白蛋白排泄量；用 Spearman 相关系数分析循环黏附分子水平与白蛋白尿之间的相关性。
我们发现糖尿病患者的循环 SAM 水平明显高于对照组（p < 0.001）。当循环 SAM 水平与白蛋白尿相关时，我们发现 VCAM-1 水平与 24 小时尿白蛋白排泄量呈显著相关（r = 0.4，p < 0.02）。
我们的结果表明，VCAM-1 可能是高血压 2 型糖尿病患者肾病的一个标志物。
