Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
PLoS One. 2013 Apr 8;8(4):e60767. doi: 10.1371/journal.pone.0060767. Print 2013.
While several studies have examined the general inflammatory responses in relation to cytomegalovirus infection, the identification of the various inflammatory mediators as well as their relative importance is far from clear.
Solid organ recipients enrolled in an international multicenter trial of cytomegalovirus disease treatment (the VICTOR study) were analyzed (n = 289) (ClinicalTrials.gov NCT00431353). Plasma markers of inflammation and endothelial cell activation were assessed at baseline by enzyme immunoassays.
The major findings were: (i) Plasma levels of the CXC-chemokine interferon-inducible protein-10 (P<0.001) and C-reactive protein (P = 0.046) were independently associated with the presence of cytomegalovirus DNAemia above lower level of quantification. (ii) High levels of CC-chemokine ligand 21 (P = 0.027) and pentraxin 3 (P = 0.033) were independently associated with tissue invasive cytomegalovirus disease as opposed to cytomegalovirus syndrome.
Our findings illustrate the complex interaction between cytomegalovirus and the immune system, involving a wide range of inflammatory mediators that could be associated to disease manifestations in cytomegalovirus related disease.
虽然已有多项研究探讨了巨细胞病毒感染相关的一般炎症反应，但各种炎症介质的鉴定及其相对重要性仍远未明确。
我们对参加巨细胞病毒病治疗国际多中心试验（VICTOR 研究）的实体器官受者进行了分析（n=289）（ClinicalTrials.gov NCT00431353）。采用酶联免疫吸附法在基线时评估炎症和血管内皮细胞激活的血浆标志物。
主要发现包括：（i）血浆中趋化因子干扰素诱导蛋白-10（P<0.001）和 C 反应蛋白（P=0.046）的水平与定量下限以上的巨细胞病毒 DNA 血症的存在独立相关。（ii）CC 趋化因子配体 21（P=0.027）和五聚素 3（P=0.033）的高水平与组织侵袭性巨细胞病毒病而不是巨细胞病毒综合征独立相关。
我们的研究结果表明巨细胞病毒与免疫系统之间存在复杂的相互作用，涉及多种炎症介质，这些介质可能与巨细胞病毒相关疾病的临床表现相关。
