Menezes Renata Barbosa, de Lucena Adson Freitas, Maia Fernanda Martins, Marinho Antônia Rosivalda Teixeira
Department of Emergency, Fortaleza's General Hospital, Fortaleza, Ceara, Brazil.
BMJ Case Rep. 2013 Apr 16;2013:bcr2012008201. doi: 10.1136/bcr-2012-008201.
Limbic encephalitis is a syndrome characterised by irritability, depression, sleeping disturbance, convulsion, hallucination and short-period memory loss that is commonly associated with a malignancy even if there is no evidence of it by the time of presentation. Most reported cases of limbic encephalitis as a paraneoplastic syndrome are associated with small-cell lung cancer and lymphoma. This article is a case report of a patient with limbic encephalitis associated with an oesophageal adenocarcinoma. The patient is a middle-aged man who presented apathy and unstable mood. After months, developed diplopia, reduced visual acuity and involuntary movements. Later, gait disability, disorientation, memory loss and aggressive behaviour were detected, associated with seizures. After investigation, limbic encephalitis was diagnosed and, as the patient developed dysphagia, oesophageal adenocarcinoma was detected. Oesophageal carcinoma usually does not have neurological symptoms associated.
边缘叶脑炎是一种以易怒、抑郁、睡眠障碍、惊厥、幻觉和短期记忆丧失为特征的综合征，即使在就诊时没有恶性肿瘤的证据，它也通常与恶性肿瘤相关。大多数作为副肿瘤综合征报道的边缘叶脑炎病例与小细胞肺癌和淋巴瘤有关。本文是一例与食管腺癌相关的边缘叶脑炎患者的病例报告。该患者为中年男性，表现为冷漠和情绪不稳定。数月后，出现复视、视力下降和不自主运动。后来，检测到步态障碍、定向障碍、记忆丧失和攻击性行为，并伴有癫痫发作。经过检查，诊断为边缘叶脑炎，由于患者出现吞咽困难，检测到食管腺癌。食管癌通常不伴有神经症状。
