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一例副肿瘤性脱髓鞘性运动性多发性神经病。

A case of paraneoplastic demyelinating motor polyneuropathy.

作者信息

Mostoufizadeh Sohrab, Souri Maryam, de Seze Jérôme

机构信息

Département de Neurologie, Hôpitaux Universitaires, Strasbourg, France.

出版信息

Case Rep Neurol. 2012 Jan;4(1):71-6. doi: 10.1159/000338296. Epub 2012 Apr 25.

Abstract

Peripheral neuropathy is commonly accompanied by cancer but demyelinating ones are not commonly reported. We report the clinical, neurophysiological, and biological characteristics of an 82-year-old patient who presented with a demyelinating motor neuropathy and high titre of anti-ganglioside antibodies associated with oesophageal cancer. The neurological course worsened rapidly despite immunotherapy, leading to a bedridden status. We propose to suspect a paraneoplastic origin in older patients or when the clinical course progresses rapidly within a few weeks or months.

摘要

周围神经病变常与癌症相伴,但脱髓鞘性周围神经病变并不常见。我们报告了一名82岁患者的临床、神经生理学及生物学特征,该患者表现为脱髓鞘性运动神经病变,并伴有与食管癌相关的高滴度抗神经节苷脂抗体。尽管进行了免疫治疗,神经病变仍迅速恶化,导致患者卧床不起。我们建议,对于老年患者或临床病程在数周或数月内迅速进展的情况,应怀疑副肿瘤性病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffc/3362224/f49b0a022032/crn-0004-0071-g01.jpg

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