运动回路中 5-羟色胺能神经元缺失与 PD 动作性姿势震颤严重程度相关。
Serotonergic loss in motor circuitries correlates with severity of action-postural tremor in PD.
机构信息
Department of Medicine, Division of Brain Sciences, Hammersmith Hospital, Imperial College London, UK.
出版信息
Neurology. 2013 May 14;80(20):1850-5. doi: 10.1212/WNL.0b013e318292a31d. Epub 2013 Apr 17.
Abstract
OBJECTIVE
The underlying pathophysiology of tremor in Parkinson disease (PD) is unclear; however, it is known that tremor does not appear to be as responsive to dopaminergic medication as bradykinesia or rigidity. It is suggested that serotonergic dysfunction could have a role in tremor development.
METHODS
Using (11)C-DASB PET, a marker of serotonin transporter binding, and clinical observations, we have investigated function of serotonergic terminals in 12 patients with tremor-predominant and 12 with akinetic-rigid PD. Findings were compared with those of 12 healthy controls.
RESULTS
Reductions of (11)C-DASB in caudate, putamen, and raphe nuclei significantly correlated with tremor severity on posture and action, but not with resting tremor. The tremor-predominant group also showed reductions of (11)C-DASB in other regions involved in motor circuitry, including the thalamus and Brodmann areas 4 and 10.
CONCLUSIONS
Our findings support a role for serotonergic dysfunction in motor circuitries in the generation of postural tremor in PD.
摘要
目的
帕金森病（PD）震颤的潜在病理生理学机制尚不清楚；然而，众所周知，震颤对多巴胺能药物的反应似乎不如运动迟缓或僵硬敏感。有人认为 5-羟色胺能功能障碍可能在震颤发展中起作用。
方法
我们使用（11）C-DASB PET（一种 5-羟色胺转运体结合的标志物）和临床观察，研究了 12 例震颤为主型和 12 例运动不能-僵硬型 PD 患者的 5-羟色胺能终末功能。将结果与 12 名健康对照者进行比较。
结果
尾状核、壳核和中缝核内（11）C-DASB 的减少与姿势和动作性震颤的严重程度显著相关，但与静止性震颤无关。震颤为主组还显示出其他涉及运动回路的区域（包括丘脑和布罗德曼区 4 和 10）内（11）C-DASB 的减少。
结论
我们的发现支持 5-羟色胺能功能障碍在 PD 姿势性震颤产生中的运动回路中的作用。
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