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从多能二苯乙烯到具有抗增殖特性的可溶性环氧化物水解酶抑制剂。

From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties.

机构信息

Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany.

出版信息

ChemMedChem. 2013 Jun;8(6):919-23. doi: 10.1002/cmdc.201300057. Epub 2013 Apr 17.

DOI:10.1002/cmdc.201300057
PMID:23596124
Abstract

Inspired by nature: Natural product isopropylstilbene was identified as an inhibitor of soluble epoxide hydrolase exhibiting antiproliferative properties. Following the natural product inspired design approach, a library of (E)-styryl-1H-benzo[d]imidazoles was synthesized and evaluated with recombinant enzyme and on several cancer cell lines.

摘要

受自然启发

天然产物异戊烯基二苯乙烯被鉴定为具有抗增殖特性的可溶性环氧化物水解酶抑制剂。受天然产物启发的设计方法的指导，合成了（E）-苯乙烯基-1H-苯并[d]咪唑类化合物库，并在重组酶和几种癌细胞系上进行了评估。

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