Incretin therapy and islet pathology: a time for caution.
作者信息
Kahn Steven E
机构信息
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
出版信息
Diabetes. 2013 Jul;62(7):2178-80. doi: 10.2337/db13-0520. Epub 2013 Apr 17.
Abstract
摘要
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Incretin therapy and islet pathology: a time for caution.肠促胰岛素治疗与胰岛病理学：需谨慎对待的时候了。
Diabetes. 2013 Jul;62(7):2178-80. doi: 10.2337/db13-0520. Epub 2013 Apr 17.
2
Comment on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604.评论：巴特勒等人。在患有外分泌胰腺发育异常增加且有产生胰高血糖素的神经内分泌肿瘤潜在风险的人类中，肠促胰岛素疗法使外分泌和内分泌胰腺显著扩张。《糖尿病》2013年；62卷：2595 - 2604页。
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3
Comment on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604.评论：巴特勒等人。在患有外分泌胰腺发育异常增加及存在产生胰高血糖素的神经内分泌肿瘤可能性的人类中，肠促胰岛素疗法可使外分泌和内分泌胰腺显著扩张。《糖尿病》2013年；62卷：2595 - 2604页。
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Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604.对关于以下内容的评论的回应：巴特勒等人。在患有外分泌胰腺发育异常增加和产生胰高血糖素的神经内分泌肿瘤潜在风险的人类中，肠促胰岛素治疗使外分泌和内分泌胰腺显著扩张。《糖尿病》2013年；62卷：2595 - 2604页。
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Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (GRADE).糖尿病血糖降低方法的原理和设计：一项比较效果研究（GRADE）。
Diabetes Care. 2013 Aug;36(8):2254-61. doi: 10.2337/dc13-0356. Epub 2013 May 20.
2
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors.外分泌和内分泌胰腺在具有外分泌胰腺发育不良增加的人类中随着肠促胰岛素治疗而显著扩张，并且具有产生胰高血糖素的神经内分泌肿瘤的潜力。
Diabetes. 2013 Jul;62(7):2595-604. doi: 10.2337/db12-1686. Epub 2013 Mar 22.
3
Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study.基于胰高血糖素样肽 1 的治疗与 2 型糖尿病患者急性胰腺炎住院风险的相关性：一项基于人群的匹配病例对照研究。
JAMA Intern Med. 2013 Apr 8;173(7):534-9. doi: 10.1001/jamainternmed.2013.2720.
4
Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.患有1型糖尿病相关自身抗体且有患病风险个体的胰腺器官重量。
JAMA. 2012 Dec 12;308(22):2337-9. doi: 10.1001/jama.2012.15008.
5
Pancreatic volume is reduced in adult patients with recently diagnosed type 1 diabetes.成年 1 型糖尿病患者的胰腺体积减小。
J Clin Endocrinol Metab. 2012 Nov;97(11):E2109-13. doi: 10.1210/jc.2012-1815. Epub 2012 Aug 9.
6
The human GLP-1 analog liraglutide and the pancreas: evidence for the absence of structural pancreatic changes in three species.人 GLP-1 类似物利拉鲁肽与胰腺：三种动物模型中胰腺结构无改变的证据。
Diabetes. 2012 May;61(5):1243-9. doi: 10.2337/db11-0936. Epub 2012 Feb 14.
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Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice.二肽基肽酶-4 抑制剂可减少链脲佐菌素诱导的小鼠糖尿病模型中胰岛β细胞的死亡和胰岛α细胞的增殖。
Diabetologia. 2012 Feb;55(2):404-12. doi: 10.1007/s00125-011-2365-4. Epub 2011 Nov 10.
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Diabetes. 2011 Sep;60(9):2308-14. doi: 10.2337/db11-0203.
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Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice.胰高血糖素受体缺陷小鼠中的胰腺神经内分泌肿瘤。
PLoS One. 2011;6(8):e23397. doi: 10.1371/journal.pone.0023397. Epub 2011 Aug 10.
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β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition.在人类 2 型糖尿病中，β 细胞的丧失和β 细胞凋亡与胰岛淀粉样沉积有关。
Am J Pathol. 2011 Jun;178(6):2632-40. doi: 10.1016/j.ajpath.2011.02.036.
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