Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC-LSCI, BCH 3305, Lausanne, CH 1015, Switzerland.
Chem Asian J. 2013 Jun;8(6):1068-75. doi: 10.1002/asia.201300232. Epub 2013 Apr 17.
[Fe]-hydrogenase is a newly characterized type of hydrogenase. This enzyme heterolytically splits hydrogen in the presence of a natural substrate. The active site of the enzyme contains a mono-iron complex with intriguing iron-acyl ligation. Several groups have recently developed iron-acyl complexes as synthetic models of [Fe]-hydrogenase. This Focus Review summarizes the studies of this enzyme and its model compounds, with an emphasis on our own research in this area.
[Fe]-氢化酶是一种新表征的氢化酶。该酶在天然底物存在的情况下异裂解氢气。酶的活性部位含有一个单核铁配合物，具有有趣的铁酰基配位。最近有几个小组已经开发出铁酰基配合物作为[Fe]-氢化酶的合成模型。本重点综述总结了该酶及其模型化合物的研究，重点介绍了我们在该领域的研究。
