胃癌患者血小板活化及吞噬活性的评估
Assessment of platelet activation and phagocytic activity in gastric cancer patients.
作者信息
Matowicka-Karna Joanna, Kamocki Zbigniew, Kemona Halina
机构信息
Joanna Matowicka-Karna, Halina Kemona, Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
出版信息
World J Gastrointest Pathophysiol. 2013 Feb 15;4(1):12-7. doi: 10.4291/wjgp.v4.i1.12.
AIM
To assess the activation of platelets and their phagocytic activity in the course of gastric cancer.
METHODS
Forty-three gastric cancer patients were recruited to the study. The patients were divided into 3 groups depending on tumor stage. Group E included 6 patients with early gastric cancer; group A 18 patients with locally advanced cancer; and group M-19 with metastatic cancer. The investigations were performed twice, prior to surgery and 12-14 d afterwards.
RESULTS
The platelet count and the level of soluble platelet selectin (sP-selectin) were found to increase with the disease progression. The level of sP-selectin was lowest in early cancer and was observed to increase after surgery in all the study patients. Irrespective of tumor stage, a statistically significant decrease was noted in the percentage of phagocytizing platelets and in the phagocytic index in gastric cancer patients as compared to healthy subjects. Despite increased platelet count and stimulation of thrombocytopoiesis, the phagocytic functions of blood platelets were markedly impaired. Tumor development seems to impair metabolic processes.
CONCLUSION
A decreasing phagocytic activity can promote both inflammatory processes and cancer growth.
目的
评估胃癌病程中血小板的激活及其吞噬活性。
方法
43例胃癌患者纳入本研究。根据肿瘤分期将患者分为3组。E组包括6例早期胃癌患者；A组18例局部进展期癌患者；M组19例转移性癌患者。在手术前及术后12 - 14天进行两次检查。
结果
发现血小板计数和可溶性血小板选择素（sP - 选择素）水平随疾病进展而升高。sP - 选择素水平在早期癌症中最低，且在所有研究患者术后均观察到升高。与健康受试者相比，无论肿瘤分期如何，胃癌患者吞噬血小板的百分比和吞噬指数均有统计学意义的下降。尽管血小板计数增加且血小板生成受到刺激，但血小板的吞噬功能明显受损。肿瘤发展似乎会损害代谢过程。
结论
吞噬活性降低可促进炎症过程和癌症生长。
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