Mantur M, Kemona H, Kozłowski R, Kemona-Chetnik I
Department of Laboratory Diagnostics, Medical Academy of Bialystok, Bialystok, 15-274 Poland.
Neoplasma. 2003;50(4):262-5.
The CD62P receptor and its soluble form sP-selectin is a marker of platelet (PLT) activation, and constitutes a ligand for CD24 antigen of neoplastic cells and tumor stroma components. The aim of the study was to evaluate the relationship dynamics of the percentage of CD62P+ platelets, the level of the receptor expression and the concentration of soluble form of sP-selectin in renal cancer. Examinations were performed before and after nephrectomy in patients with renal cancer (group A - 25, T2N0M0; group B - 27, T2N1-2M0) and in control group (C - 24 subjects). The two groups A and B showed an increased subpopulation of CD62P+ platelets (p<0.01) and elevated sP-selectin concentration (p<0.001) before and after nephrectomy. Although following nephrectomy sP-selectin concentration decreased markedly, it was still higher 3 months after the procedure compared to control group (p<0.05). Following nephrectomy, however, no statistically significant differences were found in the % of CD62P+ platelets and the receptor expression. Greater dynamics of changes before and after nephrectomy in the percentage of CD62P+ platelets (B1:B2 p<0.05) and the receptor expression (B1:B3 p<0.001) was observed in patients with local lymph node involvement (group B) while sP-selectin concentration was similar in both groups. Nephrectomy did not normalize intravascular activation of PLT and TNM had no significant effect on the expression of CD62P and concentration of sP-selectin.
CD62P受体及其可溶性形式sP-选择素是血小板（PLT）活化的标志物，并且构成肿瘤细胞和肿瘤基质成分的CD24抗原的配体。本研究的目的是评估肾癌中CD62P +血小板百分比、受体表达水平和sP-选择素可溶性形式浓度之间的关系动态变化。对肾癌患者（A组-25例，T2N0M0；B组-27例，T2N1-2M0）和对照组（C组-24名受试者）在肾切除术前和术后进行检查。A组和B组在肾切除术前和术后均显示CD62P +血小板亚群增加（p<0.01）和sP-选择素浓度升高（p<0.001）。虽然肾切除术后sP-选择素浓度明显下降，但与对照组相比，术后3个月仍较高（p<0.05）。然而，肾切除术后，CD62P +血小板百分比和受体表达未发现统计学上的显著差异。在有局部淋巴结受累的患者（B组）中观察到肾切除术前和术后CD62P +血小板百分比（B1:B2 p<0.05）和受体表达（B1:B3 p<0.001）变化的动态更大，而两组中sP-选择素浓度相似。肾切除术未能使PLT的血管内活化正常化，TNM对CD62P的表达和sP-选择素的浓度没有显著影响。
