Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Nat Rev Immunol. 2013 May;13(5):309-20. doi: 10.1038/nri3442. Epub 2013 Apr 19.
T cells function locally. Accordingly, T cells' recognition of antigen, their subsequent activation and differentiation, and their role in the processes of infection control, tumour eradication, autoimmunity, allergy and alloreactivity are intrinsically coupled with migration. Recent discoveries revise our understanding of the regulation and patterns of T cell trafficking and reveal limitations in current paradigms. Here, we review classic and emerging concepts, highlight the challenge of integrating new observations with existing T cell classification schemes and summarize the heuristic framework provided by viewing T cell differentiation and function first through the prism of migration.
T 细胞在局部发挥功能。因此，T 细胞对抗原的识别、随后的激活和分化，以及它们在感染控制、肿瘤清除、自身免疫、过敏和同种异体反应过程中的作用，都与迁移内在地联系在一起。最近的发现改变了我们对 T 细胞迁移的调控和模式的理解，并揭示了当前范式的局限性。在这里，我们回顾了经典和新兴的概念，强调了将新的观察结果与现有的 T 细胞分类方案整合的挑战，并总结了通过首先从迁移的角度来看待 T 细胞分化和功能提供的启发式框架。
