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评论“果蝇剂量补偿涉及增强的 Pol II 募集到雄性 X 连锁启动子”。

Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters".

机构信息

Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Science. 2013 Apr 19;340(6130):273. doi: 10.1126/science.1231815.

DOI:10.1126/science.1231815
PMID:23599463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3665607/
Abstract

Conrad et al. (Reports, 10 August 2012, p. 742) reported a doubling of RNA polymerase II (Pol II) occupancy at X-linked promoters to support 5' recruitment as the key mechanism for dosage compensation in Drosophila. However, they employed an erroneous data-processing step, overestimating Pol II differences. Reanalysis of the data fails to support the authors' model for dosage compensation.

摘要

康拉德等人（2012 年 8 月 10 日，第 742 页）在报告中指出，RNA 聚合酶 II（Pol II）在 X 连锁启动子上的占有率增加了一倍，以支持 5'募集，这是果蝇中剂量补偿的关键机制。然而，他们采用了一个错误的数据处理步骤，高估了 Pol II 的差异。对数据的重新分析不支持作者提出的剂量补偿模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/3665607/a3603ca5bd32/nihms-475821-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/3665607/e21b2ecaab01/nihms-475821-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/3665607/a3603ca5bd32/nihms-475821-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/3665607/e21b2ecaab01/nihms-475821-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/3665607/a3603ca5bd32/nihms-475821-f0002.jpg

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1
Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters.果蝇剂量补偿涉及增强的 Pol II 募集到雄性 X 连锁启动子。
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2
Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription.果蝇中的剂量补偿：染色体范围转录的表观遗传精细调控。
Nat Rev Genet. 2012 Jan 18;13(2):123-34. doi: 10.1038/nrg3124.
3
X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila.
RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation.
果蝇中的 RNA-on-X1 和 RNA-on-X2 在剂量补偿中发挥着不同的功能。
PLoS Genet. 2018 Dec 10;14(12):e1007842. doi: 10.1371/journal.pgen.1007842. eCollection 2018 Dec.
4
Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains.非规范果蝇 X 染色体剂量补偿和抑制性拓扑关联域。
Epigenetics Chromatin. 2018 Oct 24;11(1):62. doi: 10.1186/s13072-018-0232-y.
5
The X-linked 1.688 Satellite in Promotes Specific Targeting by Painting of Fourth.X 连锁的 1.688 卫星通过第四染色体重组促进特定靶向。
Genetics. 2018 Feb;208(2):623-632. doi: 10.1534/genetics.117.300581. Epub 2017 Dec 13.
6
Dosage Compensation in Drosophila-a Model for the Coordinate Regulation of Transcription.果蝇中的剂量补偿——转录协同调控的模型
Genetics. 2016 Oct;204(2):435-450. doi: 10.1534/genetics.115.185108.
7
Recent progress and open questions in Drosophila dosage compensation.果蝇剂量补偿的最新进展与未解决问题。
Fly (Austin). 2015;9(1):29-35. doi: 10.1080/19336934.2015.1074786.
8
Increased expression of X-linked genes in mammals is associated with a higher stability of transcripts and an increased ribosome density.哺乳动物中X连锁基因表达的增加与转录本更高的稳定性和核糖体密度的增加有关。
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9
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PeerJ. 2015 Feb 17;3:e771. doi: 10.7717/peerj.771. eCollection 2015.
10
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Mol Cell. 2014 Jun 19;54(6):920-931. doi: 10.1016/j.molcel.2014.04.013. Epub 2014 May 15.
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4
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5
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