评论“果蝇剂量补偿涉及增强的 Pol II 募集到雄性 X 连锁启动子”。
Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters".
机构信息
Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Science. 2013 Apr 19;340(6130):273. doi: 10.1126/science.1231815.
Abstract
Conrad et al. (Reports, 10 August 2012, p. 742) reported a doubling of RNA polymerase II (Pol II) occupancy at X-linked promoters to support 5' recruitment as the key mechanism for dosage compensation in Drosophila. However, they employed an erroneous data-processing step, overestimating Pol II differences. Reanalysis of the data fails to support the authors' model for dosage compensation.
摘要
康拉德等人（2012 年 8 月 10 日，第 742 页）在报告中指出，RNA 聚合酶 II（Pol II）在 X 连锁启动子上的占有率增加了一倍，以支持 5'募集，这是果蝇中剂量补偿的关键机制。然而，他们采用了一个错误的数据处理步骤，高估了 Pol II 的差异。对数据的重新分析不支持作者提出的剂量补偿模型。
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本文引用的文献
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Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters.果蝇剂量补偿涉及增强的 Pol II 募集到雄性 X 连锁启动子。
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