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骨保护素及骨保护素配体在骨巨细胞瘤中的表达及其临床意义

Expression of osteoprotegerin and osteoprotegerin ligand in giant cell tumor of bone and its clinical significance.

作者信息

Yu Xiuchun, Kong Weiqing, Zheng Kai

机构信息

Orthopedic Department, The General Hospital of Jinan Military Commanding Region, Jinan, Shandong 250031, P.R. China.

出版信息

Oncol Lett. 2013 Apr;5(4):1133-1139. doi: 10.3892/ol.2013.1199. Epub 2013 Feb 19.

DOI:10.3892/ol.2013.1199
PMID:23599752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3629272/
Abstract

In this study, we used a substance P (SP) immunohistochemical method to analyze the expression localization of osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) in giant cell tumor (GCT) of the bone, and to detect the clinical significance of their expression. The data showed that the positive expression rate of OPG in the multinucleated giant cells (MGCs) and stromal cells (STCs) of GCT was 80.65 and 74.19%, respectively. The positive expression rate of OPG in MGCs was correlated with age and prognosis (P<0.05), but not in STCs. The strength of positive OPG expression in MGCs and STCs was negatively correlated with prognosis (rs=-0.397, P<0.05; rs=-0.390, P<0.05, respectively). The positive expression rate of OPGL in the MGCs and STCs was 41.94 and 67.74%, respectively. The positive expression rate of OPGL in the MGCs was correlated with age and prognosis (P<0.05); the strength of OPGL expression in MGCs was positively correlated with Campanicci's grade and recurrence. Additionally, the positive expression rate of OPGL in STCs was correlated with age and Jaffe's grade (P<0.05). The strength of OPGL expression in STCs was negatively correlated with Jaffe's grade (rs=-0.534, P<0.05). In conclusion, OPG and OPGL are expressed in MGCs and STCs in GCT of the bone. The invasion of tumor cells was positively correlated with OPGL in MGCs, which confirmed that MGCs participate in the process of osteolytic destruction of GCT of bone.

摘要

在本研究中，我们采用P物质（SP）免疫组化方法分析骨巨细胞瘤（GCT）中骨保护素（OPG）和骨保护素配体（OPGL）的表达定位，并检测其表达的临床意义。数据显示，GCT的多核巨细胞（MGCs）和基质细胞（STCs）中OPG的阳性表达率分别为80.65%和74.19%。MGCs中OPG的阳性表达率与年龄和预后相关（P<0.05），而STCs中则无此相关性。MGCs和STCs中OPG阳性表达强度与预后呈负相关（rs=-0.397，P<0.05；rs=-0.390，P<0.05）。MGCs和STCs中OPGL的阳性表达率分别为41.94%和67.74%。MGCs中OPGL的阳性表达率与年龄和预后相关（P<0.05）；MGCs中OPGL的表达强度与Campanicci分级和复发呈正相关。此外，STCs中OPGL的阳性表达率与年龄和Jaffe分级相关（P<0.05）。STCs中OPGL的表达强度与Jaffe分级呈负相关（rs=-0.534，P<0.05）。总之，OPG和OPGL在骨GCT的MGCs和STCs中表达。肿瘤细胞的侵袭与MGCs中OPGL呈正相关，这证实了MGCs参与了骨GCT的溶骨破坏过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/95651580df45/OL-05-04-1133-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/04e6a836eafe/OL-05-04-1133-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/d21a9d0e3187/OL-05-04-1133-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/f0e0ec4e4147/OL-05-04-1133-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/047c7a5f21e0/OL-05-04-1133-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/95651580df45/OL-05-04-1133-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/04e6a836eafe/OL-05-04-1133-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/d21a9d0e3187/OL-05-04-1133-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/f0e0ec4e4147/OL-05-04-1133-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/047c7a5f21e0/OL-05-04-1133-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5640/3629272/95651580df45/OL-05-04-1133-g04.jpg

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