Li Xiaolong, Zhao Cui, Hu Dandan, Yu Yang, Gao Jin, Zhao Wenchuan, Gao Ming
Department of Head and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China ;
Oncol Lett. 2013 Apr;5(4):1412-1416. doi: 10.3892/ol.2013.1202. Epub 2013 Feb 19.
Papillary thyroid carcinoma (PTC) is often clinically multifocal. In this study, the clinicopathological characteristics of a total of 347 PTC patients treated between 2006 and 2007 were investigated in order to assess the risk factors for tumor recurrence in patients with multifocal PTC. Of all the PTC cases reviewed, 35 (10%) were categorized as multifocal PTC. Patients with multifocal PTC were significantly more likely to have extrathyroidal extension, lymph node metastases and disease recurrence (P<0.05). Hemithyroidectomy resulted in a significantly higher incidence of tumor recurrence in patients with ipsilateral multifocal PTC compared with unifocal PTC patients (P<0.01). In conclusion, hemithyroidectomy was associated with tumor recurrence in patients with ipsilateral multifocal PTC but not those with unifocal PTC. Hemithyroidectomy should only be carried out after careful deliberation when involving patients with ipsilateral multifocal PTC.
甲状腺乳头状癌（PTC）在临床上常为多灶性。本研究调查了2006年至2007年间接受治疗的347例PTC患者的临床病理特征，以评估多灶性PTC患者肿瘤复发的危险因素。在所有回顾的PTC病例中，35例（10%）被归类为多灶性PTC。多灶性PTC患者更易出现甲状腺外侵犯、淋巴结转移及疾病复发（P<0.05）。与单灶性PTC患者相比，半甲状腺切除术导致同侧多灶性PTC患者肿瘤复发的发生率显著更高（P<0.01）。总之，半甲状腺切除术与同侧多灶性PTC患者的肿瘤复发有关，但与单灶性PTC患者无关。对于同侧多灶性PTC患者，半甲状腺切除术应在仔细权衡后进行。
