Zharinov G M, Neklasova N Iu, Zimin A A
Vopr Onkol. 2012;58(6):817-20.
Kinetic parameters of prostate-specific antigen (PSA) play a pivotal role in diagnostic and treatment of patients with prostate cancer (PCr). Assessment of PSA doubling time (PSADT) can be used for monitoring of treatment efficacy and predicting the outcomes of disease. The aim of the present paper is to analyze the PSADT in patients with different spread of PCr. Moreover, the initial PSADTs were studied with relation to overall survival. 336 PCr patients were included into the study. PSADT was measured usng two point method. Ill patients had localized PCr (T1-2N0M0), 90--regional-local PCr (T1-2N0M0) and 136 had generalized PCr (T1-4N1-2M1).
Median PSADT in patients with generalized PCr amounted to 2,93 months and was significantly lower as compared to groups of patients with local and regional-local spread of disease--15,2 and 13,2 months respectively. Follow-up results revealed the link between PSADT and survival rates: the lower is PSADT, the worse are survival rates.
前列腺特异性抗原（PSA）的动力学参数在前列腺癌（PCr）患者的诊断和治疗中起着关键作用。评估PSA倍增时间（PSADT）可用于监测治疗效果和预测疾病转归。本文旨在分析不同扩散程度的PCr患者的PSADT。此外，还研究了初始PSADT与总生存期的关系。336例PCr患者纳入本研究。采用两点法测量PSADT。111例患者为局限性PCr（T1-2N0M0），90例为区域局限性PCr（T1-2N0M0），136例为广泛性PCr（T1-4N1-2M1）。
广泛性PCr患者的中位PSADT为2.93个月，与疾病局部和区域局部扩散组相比显著更低，局部和区域局部扩散组的中位PSADT分别为15.2个月和13.2个月。随访结果揭示了PSADT与生存率之间的联系：PSADT越低，生存率越差。
