Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Respirology. 2013 Jul;18(5):774-83. doi: 10.1111/resp.12097.
Polymorphisms in GSTM1 and GSTT1 may be associated with asthma risk, yet several studies and meta-analyses have reported inconclusive results. Therefore, an updated meta-analysis was conducted. Literature searches were performed using the Pubmed, Embase and Web of Science databases until October 2012. Variant 'null' genotype was compared with wild-type 'present' in the pooled data. All statistical analyses were performed using STATA 11.0. A total of 26 case-control studies were suitable for inclusion in the meta-analysis. In the overall population, a significant association was found for both the GSTM1 (odds ratio (OR) = 1.452; 95% confidence interval (CI): 1.192-1.770) and GSTT1 polymorphism (OR = 1.792; 95% CI:1.293-2.483). For subgroup analysis by age, GSTM1 significantly increased risk for both children (OR = 1.368; 95% CI: 1.051-1.781) and adults (OR = 1.859; 95% CI: 1.183-2.921). For GSTT1, a significant association was only found in the adult population (OR = 2.312; 95%CI: 1.204-4.439). Based on subgroup analysis by ethnicity, a significant association for GSTM1 was found in Europe (OR = 1.303; 95% CI: 1.018-1.667), Africa (OR = 2.175; 95%CI: 1.560-3.031) and Latin America (OR = 2.265; 95%CI: 1.375-3.729). For GSTT1, significantly increased risk was found only for Asian (OR = 2.105; 95% CI: 1.101-4.025) and Russian (OR = 2.747; 95% CI: 1.071-7.046) populations. This meta-analysis provides evidence that GSTM1 and GSTT1 polymorphisms may be risk factors for asthma.
GSTM1 和 GSTT1 基因多态性可能与哮喘风险相关，但多项研究和荟萃分析结果并不一致。因此，我们进行了一项更新的荟萃分析。我们使用 Pubmed、Embase 和 Web of Science 数据库进行文献检索，检索时间截至 2012 年 10 月。在汇总数据中，将变体“缺失”基因型与野生型“存在”进行比较。所有统计分析均使用 STATA 11.0 进行。共有 26 项病例对照研究适合纳入荟萃分析。在总体人群中，GSTM1（比值比（OR）=1.452；95%置信区间（CI）：1.192-1.770）和 GSTT1 多态性（OR=1.792；95%CI：1.293-2.483）均存在显著相关性。按年龄进行亚组分析时，GSTM1 显著增加了儿童（OR=1.368；95%CI：1.051-1.781）和成人（OR=1.859；95%CI：1.183-2.921）的哮喘风险。对于 GSTT1，仅在成年人群中发现存在显著相关性（OR=2.312；95%CI：1.204-4.439）。根据种族的亚组分析，在欧洲（OR=1.303；95%CI：1.018-1.667）、非洲（OR=2.175；95%CI：1.560-3.031）和拉丁美洲（OR=2.265；95%CI：1.375-3.729），GSTM1 存在显著相关性。对于 GSTT1，仅在亚洲（OR=2.105；95%CI：1.101-4.025）和俄罗斯（OR=2.747；95%CI：1.071-7.046）人群中发现哮喘风险显著增加。本荟萃分析提供的证据表明，GSTM1 和 GSTT1 基因多态性可能是哮喘的危险因素。
