Nguyen Hoa Van, Sanchaisuriya Kanokwan, Nguyen Dung, Phan Hoa Thi Thuy, Siridamrongvattana Sirivara, Sanchaisuriya Pattara, Fucharoen Supan, Fucharoen Goonnapa, Schelp Frank P
Graduate School, Khon Kaen University, Khon Kaen, Thailand.
Hemoglobin. 2013;37(4):333-42. doi: 10.3109/03630269.2013.790829. Epub 2013 Apr 19.
A community-based assessment of thalassemias and hemoglobinopathies was conducted at the Thua Thien Hue Province, Central Vietnam. By cluster sampling, a total of 410 pregnant women attending the antenatal care service at 30 commune health centers were recruited consecutively from September 2011 to June 2012. Hemoglobin (Hb) analysis was performed using an automated Hb analyzer. α-Thalassemia (α-thal) genes were identified by polymerase chain reaction (PCR)-based techniques. Out of the 410 pregnant women, 2.7% carried α(0)-thal and 1.2% were β-thal carriers. One woman with the - -(THAI) deletion was also found. Among the females under survey, structural Hb variants with 3.2% Hb E [β26(B8)Glu→Lys, GAG>AAG; HBB: c.78G>C] and 3.7% Hb Constant Spring [Hb CS; α142, Term→Gln, TAA>CAA (α2); HBA2: c.427T>C] were found. Assessing the frequency of thalassemias and hemoglobinopathies by ethnicity, Kinh (Vietnamese) and ethnic minority groups, Hb CS with a high frequency of 24.0% was observed in the ethnic minority groups. These results provide basic population-based information, are useful not only for implementing measures for prevention and control of thalassemias in the region but also for studying the importance of thalassemias and hemoglobinopathies in ethnic minorities within Southeast Asia.
在越南中部的广治省开展了一项基于社区的地中海贫血和血红蛋白病评估。通过整群抽样，从2011年9月至2012年6月，连续招募了30个社区卫生中心接受产前保健服务的410名孕妇。使用自动血红蛋白分析仪进行血红蛋白（Hb）分析。采用基于聚合酶链反应（PCR）的技术鉴定α地中海贫血（α-thal）基因。在410名孕妇中，2.7%携带α（0）-thal，1.2%为β-地中海贫血携带者。还发现一名携带 --(THAI) 缺失的女性。在接受调查的女性中，发现了结构血红蛋白变异体，其中Hb E [β26(B8)Glu→Lys, GAG>AAG; HBB: c.78G>C] 占3.2%，Hb Constant Spring [Hb CS; α142, Term→Gln, TAA>CAA (α2); HBA2: c.427T>C] 占3.7%。按种族评估地中海贫血和血红蛋白病的频率，在少数民族群体中观察到Hb CS的频率较高，为24.0%。这些结果提供了基于人群的基础信息，不仅有助于在该地区实施地中海贫血的防控措施，也有助于研究东南亚少数民族中地中海贫血和血红蛋白病的重要性。
