Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario M5S 3H6, Canada.
Org Lett. 2013 May 3;15(9):2128-31. doi: 10.1021/ol4006008. Epub 2013 Apr 19.
A Rh/Pd/Cu catalyst system led to an efficient synthesis of dihydroquinolinones in one-pot, two operations. The reaction features the first triple metal-catalyzed transformations in one reaction vessel, without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical.
一个 Rh/Pd/Cu 催化剂体系实现了一锅两步法高效合成二氢喹啉酮。该反应具有首例在一个反应容器中进行的三重金属催化转化，无需任何中间后处理。该串联加成/酰胺化/酰胺化反应序列具有高度的模块性、多样性和实用性。
