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机器人辅助肾门肿瘤部分切除术:围手术期结果。

Robot-assisted partial nephrectomy for hilar tumors: perioperative outcomes.

机构信息

Section of Laparoscopic and Robotic Surgery, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

出版信息

Urology. 2013 Jun;81(6):1246-51. doi: 10.1016/j.urology.2012.10.072. Epub 2013 Apr 17.

Abstract

OBJECTIVE

To compare perioperative outcomes of robot-assisted partial nephrectomy (RAPN) for hilar vs nonhilar tumors.

MATERIALS AND METHODS

The study retrospectively reviewed 364 patients with available computed tomography scans undergoing RAPN. Demographic data and perioperative outcomes results were compared between the hilar (group 1, n = 70) and nonhilar tumors (group 2, n = 294). Multivariate analysis was used to identify predictors of warm ischemia time (WIT), estimated blood loss (EBL), major perioperative complications, and postoperative renal function.

RESULTS

There were no differences with respect to demographic variables. Hilar tumors had higher RENAL (radius, exophytic/endophytic properties of the tumor, nearness of tumor deepest portion to the collecting system or sinus, anterior/posterior descriptor and the location relative to polar lines) scores (P <.001) and were larger (3.9 vs 2.6 cm, P <.001). Surgeries for hilar tumors were associated with greater operative time (210 vs 180 minutes, P <.001), longer WIT (27 vs 17 minutes, P <.001), and increased EBL (250 vs 200 mL, P = .04). No differences were noted in transfusion rate, length of stay, complications (overall and major) and positive margins. Postoperative estimated glomerular filtration rate showed no significant difference between hilar vs nonhilar patients on postoperative day 3 (70.12 vs 74.71 mL/min/1.73 m(2), P = .31) or at last follow-up (72.62 vs 75.78 mL/min/1.73 m(2), P = .40), respectively. Multivariate analysis found hilar location was independently associated with increased WIT without significant changes in EBL, major complications, or postoperative renal function.

CONCLUSION

RAPN represents a safe and effective procedure for hilar tumors. Hilar location for patients undergoing RAPN in a high-volume institution seems not be associated with an increased risk of transfusions, major complications, or decline of early postoperative renal function.

摘要

目的

比较机器人辅助部分肾切除术(RAPN)治疗肾门肿瘤与非肾门肿瘤的围手术期结果。

材料与方法

本研究回顾性分析了 364 例接受 RAPN 治疗且可提供 CT 扫描的患者。比较了肾门肿瘤组(第 1 组,n=70)和非肾门肿瘤组(第 2 组,n=294)的人口统计学数据和围手术期结果。使用多变量分析确定热缺血时间(WIT)、估计失血量(EBL)、主要围手术期并发症和术后肾功能的预测因素。

结果

两组患者在人口统计学变量方面无差异。肾门肿瘤的 RENAL(半径、肿瘤的外生性/内生性特征、肿瘤最深部与集合系统或窦腔的接近程度、前后描述符以及相对于极线的位置)评分更高(P<.001),且肿瘤更大(3.9 厘米比 2.6 厘米,P<.001)。肾门肿瘤手术的手术时间更长(210 分钟比 180 分钟,P<.001),WIT 更长(27 分钟比 17 分钟,P<.001),EBL 更多(250 毫升比 200 毫升,P=.04)。两组间输血率、住院时间、并发症(总发生率和主要并发症发生率)和阳性切缘率无差异。术后第 3 天(70.12 毫升/分钟/1.73 平方米与 74.71 毫升/分钟/1.73 平方米,P=.31)和最后一次随访时(72.62 毫升/分钟/1.73 平方米与 75.78 毫升/分钟/1.73 平方米,P=.40), hilar 组与 nonhilar 组的术后估算肾小球滤过率(eGFR)均无显著差异。多变量分析发现,肾门位置与 WIT 增加独立相关,EBL、主要并发症或术后肾功能无显著变化。

结论

RAPN 是治疗肾门肿瘤的一种安全有效的方法。在高容量机构中,对于接受 RAPN 治疗的患者,肾门位置似乎不会增加输血、严重并发症或早期术后肾功能下降的风险。

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