Liu Jing, Liu Zu-Guo, Shao Yi, Chen Jing-Yao, Li Wei, Lin Hui
Eye Institute of Xiamen University, Xiamen Eye Center Affiliated Xiamen University, Xiamen 361005, China.
Zhonghua Yan Ke Za Zhi. 2013 Jan;49(1):32-6.
To investigate the clinical efficiency of calf blood extract gel on dry eye induced by chronic graft versus host diseases after bone marrow transplantation.
It was a two-stage cross-over design double-blind controlled study. Twelve patients (twenty-four eyes) diagnosis dry eye induced by chronic graft versus diseases in Ocular Surface Out-patient Clinic of Xiamen University Affiliated Xiamen Eye Center 2009 from 2010 to were divide into two groups: group A accepted the treatment of autologous serum in the first stage and group B accepted the treatment of calf blood extract gel, after one month of elution, group A accepted calf blood extract gel and group B accepted autologous serum. The signs and symptoms with different therapies were recorded at the time of pre and post therapies, which were analyzed by Wilcoxon analysis and two-stage cross-over analysis.
Ocular dry eye symptoms including visual tiredness, dry and unsmooth sensation, foreign body sensation, photophobia, pain, redness and visual acuity had been improved in both autologous serum therapy (U = 22.5, 43.2, 27.0, 17.4, 21.5, 38.5, 23.0, P < 0.05) and calf blood extract gel therapy (U = 333.0, 24.5, 29.0, 40.5, 26.0, 36.0, 51.0, P < 0.05) after two-week treatment. Corneal FL had significantly been improved (2.00 ± 1.00, 3.00 ± 1.50) (Group A U = 273.0, Group B U = 135.0, P < 0.01). Ocular dry eye signs and symptoms including visual tiredness, dry and unsmooth sensation, burning sensation, photophobia, pain, tearing, redness, visual acuity, corneal FL, TFBUT and S It hadn't significantly improved between two kinds of therapies (F = 1.45, 2.43, 2.14, 1.91, 1.63, 0.51, 1.19, 0.68, 2.75, 0.77, 1.23, P > 0.05) or between two kinds of offering drug orders (F = 3.17, 2.62, 0.91, 1.42, 0.89, 2.17, 0.95, 1.54, 3.21, 6.72, 1.37, P > 0.05) in the two-stage cross-over design. Only foreign body sensation had significantly statistical difference between two kinds of drug (F = 11.38, P < 0.05), while without significant statistical difference between two kinds of offering drug orders (F = 2.62, P > 0.05).
Calf blood extract gel can be consider as a alternative for the treatment of dry eye induced by cGVHDs, because of its functions on releasing ocular dry eye symptoms and promoting corneal epithelial cells repair.
探讨小牛血提取物凝胶治疗骨髓移植后慢性移植物抗宿主病所致干眼症的临床疗效。
采用两阶段交叉设计双盲对照研究。选取2009年至2010年在厦门大学附属厦门眼科中心眼表门诊诊断为慢性移植物抗宿主病所致干眼症的12例患者（24只眼），分为两组：A组第一阶段接受自体血清治疗，B组接受小牛血提取物凝胶治疗，洗脱1个月后，A组接受小牛血提取物凝胶治疗，B组接受自体血清治疗。记录治疗前后不同治疗方法的体征和症状，采用Wilcoxon分析和两阶段交叉分析进行分析。
自体血清治疗（U = 22.5、43.2、27.0、17.4、21.5、38.5、23.0，P < 0.05）和小牛血提取物凝胶治疗（U = 333.0、24.5、29.0、40.5、26.0、36.0、51.0，P < 0.05）两周后，眼干症状包括视疲劳、干涩感、异物感、畏光、疼痛、眼红和视力均有改善。角膜荧光素染色显著改善（2.00±1.00，3.00±1.50）（A组U = 273.0，B组U = 135.0，P < 0.01）。两种治疗方法之间（F = 1.45、2.43、2.14、1.91、1.63、0.51、1.19、0.68、2.75、0.77、1.23，P > 0.05）或两种给药顺序之间（F = 3.17、2.62、0.91、1.42、0.89、2.17、0.95、1.54、3.21、6.72、1.37，P > 0.05），眼干体征和症状包括视疲劳、干涩感、烧灼感、畏光、疼痛、流泪、眼红、视力、角膜荧光素染色、泪膜破裂时间和泪液分泌均无显著改善。两种药物之间仅异物感有显著统计学差异（F = 11.38，P < 0.05），而两种给药顺序之间无显著统计学差异（F = 2.62，P > 0.05）。
小牛血提取物凝胶可作为治疗慢性移植物抗宿主病所致干眼症的替代药物，因其具有缓解眼干症状和促进角膜上皮细胞修复的作用。
