髓鞘抗原负荷影响中枢神经系统自身免疫的抗原呈递和严重程度。
Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity.
机构信息
Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
出版信息
J Neuroimmunol. 2013 Jun 15;259(1-2):37-46. doi: 10.1016/j.jneuroim.2013.03.012. Epub 2013 Apr 17.
Abstract
This study was designed to understand the impact of self-antigen load on manifestation of organ specific autoimmunity. Using a transgenic mouse model characterized by CNS hypermyelination, we show that larger myelin content results in greater severity of experimental autoimmune encephalomyelitis attributable to an increased number of microglia within the hypermyelinated brain. We conclude that a larger self-antigen load affects an increase in number of tissue resident antigen presenting cells (APCs) most likely due to compensatory antigen clearance mechanisms thereby enhancing the probability of productive T cell-APC interactions in an antigen abundant environment and results in enhanced severity of autoimmune disease.
摘要
本研究旨在了解自身抗原负荷对器官特异性自身免疫的影响。我们使用一种中枢神经系统过度髓鞘化的转基因小鼠模型，结果表明，较大的髓鞘含量导致实验性自身免疫性脑脊髓炎的严重程度增加，这归因于过度髓鞘化大脑中的小胶质细胞数量增加。我们的结论是，更大的自身抗原负荷会影响组织驻留抗原呈递细胞（APC）数量的增加，这很可能是由于补偿性抗原清除机制，从而增强了在抗原丰富的环境中有效 T 细胞-APC 相互作用的可能性，并导致自身免疫性疾病的严重程度增强。
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