Fisher Marisa M, Eugster Erica A
Department of Pediatrics, Section of Pediatric Endocrinology, Riley Hospital for Children, Indiana University School of Medicine, 705 Riley Hospital Drive, Room 5960, Indianapolis, IN 46202, United States.
Department of Pediatrics, Section of Pediatric Endocrinology, Riley Hospital for Children, Indiana University School of Medicine, 705 Riley Hospital Drive, Room 5960, Indianapolis, IN 46202, United States.
Reprod Toxicol. 2014 Apr;44:7-14. doi: 10.1016/j.reprotox.2013.03.012. Epub 2013 Apr 17.
Recent studies indicate that the onset of puberty is occurring at increasingly younger ages. Many etiologies have been hypothesized to be involved, but environmental exposures are among the most worrisome. Multiple organizations have endorsed the need to study and provide clinical awareness regarding the effect of a child's environment on pubertal timing. This review article summarizes the current understanding of the major environmental influences on pubertal timing, focusing on factors for which the most scientific evidence exists. The research reviewed addresses intrinsic factors unique to each individual, naturally occurring endocrine disruptors and chemical endocrine disruptors. In each category, evidence was found for and against the involvement of specific environmental factors on pubertal timing. Ultimately, an individual's environment is likely comprised of many aspects that collectively contribute to the timing of puberty. The need for research aimed at elucidating the effects of numerous specific yet disparate forms of exposures is emphasized.
近期研究表明,青春期的开始年龄越来越小。人们已推测出许多病因与之相关,但环境暴露是最令人担忧的因素之一。多个组织认可有必要开展研究并提高临床对儿童环境对青春期发育时间影响的认识。这篇综述文章总结了目前对影响青春期发育时间的主要环境因素的理解,重点关注存在最多科学证据的因素。所综述的研究涉及个体特有的内在因素、天然存在的内分泌干扰物和化学内分泌干扰物。在每个类别中,都发现了支持和反对特定环境因素与青春期发育时间有关的证据。最终,个体的环境可能由许多方面共同构成,这些方面共同影响青春期的发育时间。强调了开展旨在阐明众多特定但不同形式暴露影响的研究的必要性。