Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials, Ministry of Education, Shandong University, Shandong, Ji'nan 250061, People's Republic of China.
Colloids Surf B Biointerfaces. 2013 Sep 1;109:1-9. doi: 10.1016/j.colsurfb.2013.03.026. Epub 2013 Mar 27.
Calcium phosphate (CaP) coatings were prepared on Mg-Zn-Zr magnesium alloy by micro-arc oxidation (MAO) in electrolyte containing calcium acetate monohydrate (CH3COO)2Ca·H2O) and different phosphates (i.e. disodium hydrogen phosphate dodecahydrate (Na2HPO4·12H2O), sodium phosphate (Na3PO4·H2O) and sodium hexametaphosphate((NaPO3)6)). Scanning electron microscope (SEM), energy-dispersive X-ray spectrometry (EDS) and X-ray diffractometer (XRD) were employed to characterize the microstructure, elemental distribution and phase composition of the CaP coatings. Simulated body fluid (SBF) immersion test was used to evaluate the coating bioactivity and degradability. Systemic toxicity test was used to evaluate the coating biocompatibility. Fluoride ion selective electrode (ISE) was used to measure F(-) ions concentration during 30 days SBF immersion. The CaP coatings effectively reduced the corrosion rate and the surfaces of CaP coatings were covered by a new layer formed of numerous needle-like and scale-like apatites. The formation of these calcium phosphate apatites indicates that the coatings have excellent bioactivity. The coatings formed in (NaPO3)6-containging electrolyte exhibit thicker thickness, higher adhesive strength, slower degradation rate, better apatite-inducing ability and biocompatibility.
钙磷酸盐（CaP）涂层通过在含有一水合乙酸钙（（CH3COO）2Ca·H2O）和不同磷酸盐（即十二水合磷酸氢二钠（Na2HPO4·12H2O）、磷酸钠（Na3PO4·H2O）和六偏磷酸钠（（NaPO3）6）的电解液中的微弧氧化（MAO）在 Mg-Zn-Zr 镁合金上制备。采用扫描电子显微镜（SEM）、能谱仪（EDS）和 X 射线衍射仪（XRD）对 CaP 涂层的微观结构、元素分布和相组成进行了表征。采用模拟体液（SBF）浸泡试验评价涂层的生物活性和降解性。采用全身毒性试验评价涂层的生物相容性。采用氟离子选择电极（ISE）在 30 天 SBF 浸泡过程中测量 F（-）离子浓度。CaP 涂层有效降低了腐蚀速率，CaP 涂层表面覆盖着由大量针状和鳞片状磷灰石形成的新层。这些磷酸钙磷灰石的形成表明涂层具有优异的生物活性。在含有（NaPO3）6 的电解液中形成的涂层具有更厚的厚度、更高的结合强度、更慢的降解速率、更好的诱导磷灰石能力和生物相容性。
