Graduate School of Energy Science, Kyoto University, Kyoto 606-8501, Japan.
Int J Mol Sci. 2024 Jun 14;25(12):6587. doi: 10.3390/ijms25126587.
Zr-50Ti alloys are promising biomaterials due to their excellent mechanical properties and low magnetic susceptibility. However, Zr-50Ti alloys do not inherently bond well with bone. This study aims to enhance the bioactivity and bonding strength of Zr-50Ti alloys for orthopedic implant materials. Initially, the surface of Zr-50Ti alloys was treated with a sulfuric acid solution to create a microporous structure, increasing surface roughness and area. Subsequently, low crystalline calcium phosphate (L-CaP) precipitation was controlled by adding Mg and/or CO ions in modified simulated body fluid (m-SBF). The treated Zr-50Ti alloys were then subjected to cold isostatic pressing to force m-SBF into the micropores, followed by incubation to allow L-CaP formation. The apatite-forming process was tested in simulated body fluid (SBF). The results demonstrated that the incorporation of Mg and/or CO ions enabled the L-CaP to cover the entire surface of Zr-50Ti alloys within only one day. After short-term soaking in SBF, the L-CaP layer, modulated by Mg and/or CO ions, formed a uniform hydroxyapatite (HA) coating on the surface of the Zr-50Ti alloys, showing potential for optimized bone integration. After soaking in SBF for 14 days, the bonding strength between the apatite layer and alloy has the potential to meet the orthopedic application requirement of 22 MPa. This study demonstrates an effective method to enhance the bioactivity and bonding strength of Zr-50Ti alloys for orthopedic applications.
Zr-50Ti 合金因其优异的机械性能和低磁导率而成为有前途的生物材料。然而，Zr-50Ti 合金本身与骨骼的结合性并不理想。本研究旨在提高 Zr-50Ti 合金作为骨科植入材料的生物活性和结合强度。首先，用硫酸溶液处理 Zr-50Ti 合金表面，形成微孔结构，提高表面粗糙度和面积。随后，通过在改良模拟体液（m-SBF）中添加 Mg 和/或 CO 离子来控制低结晶磷酸钙（L-CaP）的沉淀。然后将处理过的 Zr-50Ti 合金进行冷等静压处理，将 m-SBF 压入微孔中，再进行孵育，以促进 L-CaP 的形成。在模拟体液（SBF）中测试了磷灰石的形成过程。结果表明，仅一天内，添加 Mg 和/或 CO 离子即可使 L-CaP 覆盖 Zr-50Ti 合金的整个表面。在 SBF 中短期浸泡后，由 Mg 和/或 CO 离子调制的 L-CaP 层在 Zr-50Ti 合金表面形成均匀的羟基磷灰石（HA）涂层，具有优化骨整合的潜力。在 SBF 中浸泡 14 天后，磷灰石层与合金之间的结合强度有可能满足骨科应用 22MPa 的要求。本研究证明了一种有效提高 Zr-50Ti 合金生物活性和结合强度的方法，可用于骨科应用。
