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Plasticity in adult and ageing sympathetic neurons.成年和衰老交感神经元的可塑性。
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Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease.腺病毒载体介导的胶质细胞源性神经营养因子基因治疗晚期帕金森病啮齿动物损伤模型。
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Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors.载体介导的神经生长因子递送：使用抗低亲和力和高亲和力神经生长因子受体抗体揭示老年大鼠基底前脑神经元的变化。
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Dose response to intraventricular glial cell line-derived neurotrophic factor administration in parkinsonian monkeys.帕金森病猴脑室内注射胶质细胞源性神经营养因子的剂量反应
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Treatment strategies for neurodegenerative diseases based on trophic factors and cell transplantation techniques.
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Behavioral and neurochemical effects of intranigral administration of glial cell line-derived neurotrophic factor on aged Fischer 344 rats.向老年Fischer 344大鼠脑黑质内注射胶质细胞源性神经营养因子的行为学和神经化学效应。
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Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.在帕金森病大鼠模型中，向纹状体内注射表达胶质细胞源性神经营养因子的腺病毒载体可预防多巴胺能神经元变性和行为障碍。
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Intracerebroventricular glial cell line-derived neurotrophic factor improves motor function and supports nigrostriatal dopamine neurons in bilaterally 6-hydroxydopamine lesioned rats.脑室内注射胶质细胞系源性神经营养因子可改善双侧6-羟基多巴胺损伤大鼠的运动功能并支持黑质纹状体多巴胺能神经元。
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神经营养因子补充对衰老的行为学影响。

Behavioral effects of neurotrophic factor supplementation in aging.

作者信息

Rose G M

出版信息

Age (Omaha). 1999 Jan;22(1):1-7. doi: 10.1007/s11357-999-0001-8.

DOI:10.1007/s11357-999-0001-8
PMID:23604385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455409/
Abstract

Neurotrophic factors are now recognized to play important roles in the normal function of the mature central nervous system. This knowledge has motivated experiments to evaluate the potential benefits of administering neurotrophic factors to the aged brain. This article provides a review of studies to date that have determined the behavioral effects of such treatments. Nerve growth factor (NGF) administration appears to reliably enhance learning and memory in aged rats, while glial-derived neurotrophic factor (GDNF) causes some improvement in motor function. Problems associated with neurotrophic factor administration to humans are discussed.

摘要

神经营养因子现在被认为在成熟中枢神经系统的正常功能中发挥重要作用。这一认识推动了相关实验，以评估向老年大脑施用神经营养因子的潜在益处。本文综述了迄今为止确定此类治疗行为效果的研究。给予神经生长因子（NGF）似乎能可靠地增强老年大鼠的学习和记忆能力，而胶质细胞源性神经营养因子（GDNF）则能使运动功能有所改善。文中还讨论了向人类施用神经营养因子相关的问题。