钴（II）配合物与牛脱辅基碳酸酐酶B的相互作用。

The interaction of cobalt (II) complexes with bovine apocarbonic anhydrase B.

作者信息

Gerber K, Ng F T, Wilkins R G

出版信息

Bioinorg Chem. 1975 Jan;4(2):153-62. doi: 10.1016/s0006-3061(00)81024-8.

Abstract

The second-order rate constants for interaction of a number of cobalt(II) complexes (including the aquated ion) with bovine apocarbonic anhydrase have been measured at pH equal to 7.5, 25 degrees C and I equal 0.1 M. The ease of entry of cobalt decreases, in general, as the number of its coordinated watersdecreases. The highest complexes (bis or tris) do not react. The Mono cobalt(II) -8-quinolinol-5-sulfonate and, particularly, 8-quinolinol complexes react very much more rapidly with apoenzyme than does Co(H20)6-2+ ion. The results are discussed.

摘要

在pH值为7.5、25摄氏度且离子强度I等于0.1M的条件下，已测定了多种钴（II）配合物（包括水合离子）与牛脱辅基碳酸酐酶相互作用的二级反应速率常数。一般来说，随着钴配位水数量的减少，钴进入的难易程度降低。最高配位的配合物（双齿或三齿）不发生反应。单钴（II）-8-喹啉醇-5-磺酸盐，特别是8-喹啉醇配合物与脱辅基酶的反应比Co(H₂O)₆²⁺离子快得多。对结果进行了讨论。