Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Neurosci Bull. 2013 Dec;29(6):761-72. doi: 10.1007/s12264-013-1336-9. Epub 2013 Apr 20.
N-Methyl-D-aspartate receptors (NMDARs) play vital roles in the central nervous system, as they are primary mediators of Ca(2+) influx during synaptic activity. The subunits that compose NMDARs share similar topological structures but are distinct in distribution and pharmacological properties, as well as physiological and pathological functions, which make the NMDAR one of the most complex and elusive ionotropic glutamate receptors. In this review, we focus on GluN2A and GluN2B, the primary NMDAR subunits in the cortex and hippocampus, and discuss their differences in developmental expression, brain distribution, trafficking, and functional properties during neuronal activity.
N-甲基-D-天冬氨酸受体（NMDARs）在中枢神经系统中发挥着重要作用，因为它们是突触活动过程中 Ca(2+)内流的主要介质。组成 NMDAR 的亚基具有相似的拓扑结构，但在分布、药理学特性以及生理和病理功能上存在差异，这使得 NMDAR 成为最复杂和难以捉摸的离子型谷氨酸受体之一。在这篇综述中，我们重点讨论皮层和海马中的主要 NMDAR 亚基 GluN2A 和 GluN2B，并讨论它们在发育表达、脑区分布、转运以及神经元活动过程中的功能特性方面的差异。
