Sun Chuan-Zheng, Li Qiu-Li, Hu Ze-Dong, Jiang Yu-E, Song Ming, Yang An-Kui
Department of Head and Neck Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
Head Neck. 2014 May;36(5):675-81. doi: 10.1002/hed.23355. Epub 2013 Jul 30.
The purpose of this study was to evaluate the outcome in sinonasal mucosal melanoma (SMM).
A retrospective analysis of clinicopathological data from January 1976 to December 2005 was performed. Survival curve, univariate, and multivariate analyses were undertaken.
Sixty-eight patients with SMM were enrolled; 3 patients refused treatment. The 3-year and 5-year overall survival (OS) rates in the remaining 65 cases of SMM were 36.5% and 29.7%, respectively. Patients who underwent surgery had better 3-year and 5-year OS rates than those treated without surgery (40.7% and 34.1% vs 21.4% and 14.3%, respectively), and the same was true for patients treated with and without biotherapy (58.2% and 50.9% vs 30.0% and 23.4%, respectively). Distant metastasis at presentation was associated with a worse prognosis. Those patients managed with multimodality treatment had better OS rates.
The prognosis in SMM is poor, particularly for those with distant metastasis or without surgery. Multimodality treatment may improve survival.
本研究的目的是评估鼻窦黏膜黑色素瘤（SMM）的治疗结果。
对1976年1月至2005年12月的临床病理数据进行回顾性分析。进行了生存曲线、单因素和多因素分析。
纳入68例鼻窦黏膜黑色素瘤患者；3例拒绝治疗。其余65例鼻窦黏膜黑色素瘤患者的3年和5年总生存率（OS）分别为36.5%和29.7%。接受手术治疗的患者3年和5年总生存率高于未接受手术治疗的患者（分别为40.7%和34.1%，对比21.4%和14.3%），接受生物治疗和未接受生物治疗的患者情况相同（分别为58.2%和50.9%，对比30.0%和23.4%）。初诊时出现远处转移与预后较差相关。接受多模式治疗的患者总生存率更高。
鼻窦黏膜黑色素瘤的预后较差，尤其是对于那些有远处转移或未接受手术治疗的患者。多模式治疗可能会提高生存率。
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