Oryu Makoto, Mori Hirohito, Kobara Hideki, Nishiyama Noriko, Fujihara Shintaro, Kobayashi Mitsuyoshi, Yasuda Mitsugu, Masaki Tsutomu
Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu, Kagawa 761-0793, Japan.
ISRN Gastroenterol. 2013 Mar 28;2013:840690. doi: 10.1155/2013/840690. Print 2013.
In Europe and the United States, the incidence of esophageal adenocarcinoma has increased 6-fold in the last 25 years and currently accounts for more than 50% of all esophageal cancers. Barrett's esophagus is the source of Barrett's adenocarcinoma and is characterized by the replacement of squamous epithelium with columnar epithelium in the lower esophagus due to chronic gastroesophageal reflux disease (GERD). Even though the prevalence of GERD has recently been increasing in Japan as well as in Europe and the United States, the clinical situation of Barrett's esophagus and Barrett's adenocarcinoma differs from that in Western countries. In this paper, we focus on specific differences in the background factors and pathophysiology of these lesions.
在欧洲和美国，食管腺癌的发病率在过去25年中增加了6倍，目前占所有食管癌的50%以上。巴雷特食管是巴雷特腺癌的起源，其特征是由于慢性胃食管反流病（GERD），食管下段的鳞状上皮被柱状上皮取代。尽管日本以及欧美国家GERD的患病率最近一直在上升，但巴雷特食管和巴雷特腺癌的临床情况与西方国家有所不同。在本文中，我们重点关注这些病变在背景因素和病理生理学方面的具体差异。
