Wada Y, Hasegawa H, Okuda H, Yamaguchi N
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Brain Dev. 1990;12(2):206-10. doi: 10.1016/s0387-7604(12)80326-3.
The acute anticonvulsant effects of zonisamide (ZNS) and phenytoin (PHT) on seizure activity produced by electrical stimulation of the feline visual cortex were studied. The intravenous administration of ZNS 60 mg/kg reduced kindled generalized seizures into partial seizures, with marked reduction in the afterdischarge duration. ZNS also suppressed focal seizure activity of the visual cortex and produced a dose-related increase in the afterdischarge threshold. The anticonvulsant effect of ZNS (60 mg/kg) was comparable to that of PHT (15 mg/kg) and was observed in the absence of neurological toxicity and background EEG changes. The present findings demonstrated that ZNS possesses potent anticonvulsant action against focal seizure and its secondary generalization from the visual cortex.
研究了唑尼沙胺（ZNS）和苯妥英（PHT）对电刺激猫视觉皮层所产生的癫痫活动的急性抗惊厥作用。静脉注射60mg/kg的ZNS可将点燃的全身性癫痫发作减少为部分性发作，后放电持续时间显著缩短。ZNS还可抑制视觉皮层的局灶性癫痫活动，并使后放电阈值呈剂量依赖性增加。ZNS（60mg/kg）的抗惊厥作用与PHT（15mg/kg）相当，且在无神经毒性和背景脑电图变化的情况下观察到。目前的研究结果表明，ZNS对视觉皮层的局灶性癫痫发作及其继发性泛化具有强大的抗惊厥作用。
