1979 年至 2009 年间，美国 SEER 剩余组织库中伯基特淋巴瘤肿瘤中的 Epstein-Barr 病毒模式。
Epstein-Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979-2009.
机构信息
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
APMIS. 2014 Jan;122(1):5-15. doi: 10.1111/apm.12078. Epub 2013 Apr 23.
Burkitt lymphoma (BL) occurs at all ages, but the patterns of Epstein-Barr virus (EBV) positivity in relation to human immunodeficiency virus (HIV), immunoprofiles and age have not been fully explored. BL tissues from residual tissue repositories, and two academic centers in the United States were examined by expert hematopathologists for morphology, immunohistochemistry, MYC rearrangement, EBV-encoded RNA (EBER), and diagnosed according to the 2008 WHO lymphoma classification. Analysis was done using frequency tables, Chi-squared statistics, and Student's t-test. Of 117 cases examined, 91 were confirmed as BL. The age distribution was 26%, 15%, 19%, and 29% for 0-19, 20-34, 35-59, 60+ years, and missing in 11%. MYC rearrangement was found in 89% and EBER positivity in 29% of 82 cases with results. EBER positivity varied with age (from 13% in age group 0-19 to 55% in age group 20-34, and fell to 25% in age group 60+ years, p = 0.08); with race (56% in Blacks/Hispanics vs 21% in Whites/Asians/Pacific Islanders, p = 0.006); and by HIV status (64% in HIV positive vs 22% in HIV negative cases, p = 0.03). EBER positivity was demonstrated in about one-third of tumors and it was strongly associated with race and HIV status, and marginally with age-group.
伯基特淋巴瘤（BL）可发生于任何年龄，但关于人类免疫缺陷病毒（HIV）、免疫表型和年龄与 EBV 阳性的关系尚未完全阐明。通过专家血液病理学家对来自美国两个学术中心和剩余组织库的 BL 组织进行形态学、免疫组化、MYC 重排、EBV 编码 RNA（EBER）检查，并根据 2008 年 WHO 淋巴瘤分类进行诊断。采用频数表、卡方检验和 Student's t 检验进行分析。在检查的 117 例病例中，91 例被确认为 BL。年龄分布为 0-19 岁、20-34 岁、35-59 岁和 60+岁的分别占 26%、15%、19%和 29%，11%缺失。在 82 例有结果的病例中，89%发现 MYC 重排，29% EBER 阳性。EBER 阳性率随年龄而变化（从 0-19 岁组的 13%到 20-34 岁组的 55%，然后降至 60+岁组的 25%，p=0.08）；随种族而变化（黑人和西班牙裔/拉丁裔为 56%，白种人/亚裔/太平洋岛民为 21%，p=0.006）；以及随 HIV 状态而变化（HIV 阳性病例为 64%，HIV 阴性病例为 22%，p=0.03）。约三分之一的肿瘤中显示 EBER 阳性，与种族和 HIV 状态密切相关，与年龄组也有一定相关性。
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