Department of Clinical and Experimental Medicine, Section of Dermatology, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy.
Eur J Dermatol. 2013 Apr 1;23(2):189-94. doi: 10.1684/ejd.2013.1987.
The chronic and relapsing nature of vulvar lichen sclerosus (VLS) represents a challenge for its long-term management after an effective treatment with topical corticosteroids.
To compare the effect of topical vitamin E with that of an emollient in reducing the risk of VLS relapse over a 52-week maintenance treatment.
156 patients with VLS were enrolled in a 12-week active treatment phase on topical 0.1% mometasone furoate ointment once daily. Those who achieved disease remission entered a 52-week maintenance phase in which patients were randomized to apply either an emollient or topical vitamin E once daily.
80 patients entered the maintenance phase. At 52 weeks, for the vitamin E maintenance group, the cumulative crude relapse rate was 27.8% and the cumulative modified crude relapse rate was 55.6%. For the emollient maintenance group, the cumulative crude relapse rate was 22.7% and the cumulative modified crude relapse rate was 50.0%. The median time to relapse was 20 weeks for the vitamin E group and 18.7 weeks for the emollient group.
Once VLS has been stabilized with topical corticosteroids, long-term treatment with both vitamin E and emollients may be considered in maintain LS remission.
外阴硬化性苔藓（VLS）具有慢性和复发性特点，这给其在经糖皮质激素有效治疗后的长期管理带来了挑战。
比较外用维生素 E 与保湿剂在减少 52 周维持治疗中 VLS 复发风险方面的效果。
156 例 VLS 患者接受 0.1%莫米松糠酸酯软膏每日 1 次的 12 周活性治疗阶段。达到疾病缓解的患者进入 52 周维持阶段，随机分为每日应用保湿剂或外用维生素 E 组。
80 例患者进入维持阶段。在 52 周时，对于维生素 E 维持组，累积粗复发率为 27.8%，累积改良粗复发率为 55.6%。对于保湿剂维持组，累积粗复发率为 22.7%，累积改良粗复发率为 50.0%。维生素 E 组的中位复发时间为 20 周，保湿剂组为 18.7 周。
在外阴硬化性苔藓经糖皮质激素稳定后，可考虑长期应用维生素 E 和保湿剂来维持缓解。
