Department of Medicine, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Clin Dermatol. 2013 May-Jun;31(3):264-81. doi: 10.1016/j.clindermatol.2012.08.008.
Melanoma cells frequently metastasize to the brain, and approximately 50% of patients with metastatic melanoma develop intracranial disease. Historically, central nervous system dissemination has portended a very poor prognosis. Recent advances in systemic therapies for melanoma, supported by improved local therapy control of brain lesions, have resulted in better median survival for these patients. We review current local and systemic approaches for patients with melanoma brain metastases.
黑色素瘤细胞常转移至脑部，约 50%的转移性黑色素瘤患者出现颅内疾病。从历史上看，中枢神经系统播散预示着预后极差。黑色素瘤的系统治疗进展，加上对脑转移瘤局部治疗的改善，使这些患者的中位生存期得到了改善。我们回顾了目前黑色素瘤脑转移患者的局部和全身治疗方法。
