铜离子与淀粉样β肽英国突变体的可溶性寡聚物结合，生成一个线性的 Cu(I)结合位点，该位点不易被 O2 氧化。
Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation.
机构信息
Department of Chemistry, University of Nevada, Reno, NV 89557, USA.
出版信息
Chem Commun (Camb). 2013 May 25;49(42):4797-9. doi: 10.1039/c3cc40326b.
Abstract
Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(II) coordination yields a square planar (N/O)4 coordination environment, while reduction yields an O2 inert linear bis-His Cu(I) centre.
摘要
研究了淀粉样β肽的英国（AβH(6)R）突变体可溶性低聚物与铜的配位情况。Cu(II)配位生成平面正方形（N/O）4配位环境，而还原生成 O2 惰性的线性双组氨酸 Cu(I)中心。
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