Knauf Y, Failing K, Knauf S, Wehrend A
Klinikum Veterinärmedizin, Klinik für Geburtshilfe, Gynäkologie und Andrologie der Groß- und Kleintiere mit Tierärztlicher Ambulanz, Justus-Liebig-Universität Gießen, Frankfurter Straße 106, Gießen.
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2013;41(2):93-100.
Ovarian cysts have great clinical relevance in bitches. Currently, ovariohysterectomy is regarded as the gold standard, but there is a paucity of information on the aetiology and hormonal treatment in this species. Standardised protocols for non-surgical treatment are, however, virtually non-existent. Reports on the success of hormonal therapy are rare and generally restricted to individual case reports. The objective of the present study was to determine the success rate of human chorionic gonadotropin (hCG) or the gonadotropin-releasing hormone analogue buserelin in a larger cohort of bitches.
A total of 30 bitches with ovarian cysts were treated with a maximum of three attempts per individual, utilising different protocols of the hCG and/or buserelin treatment.
Hormonal therapy was successful in 63% of the treated cases. There was no significant difference between the success rates of the hCG- and buserelin-based protocols. The first treatment attempted had a success rate of 40%, with 33% and 67% for the second and third treatments, respectively. The success of conservative therapy failed in the first treatment attempt in two cases, after the second in seven cases, and after the third attempt in one bitch. In these 10 cases, an ovariohysterectomy was performed.
The hormonal therapy of ovarian cysts in bitches provides an acceptable alternative to the current gold standard of ovariohysterectomy, especially to avoid negative side-effects of spaying. However, conservative therapy requires a pre-interventional health check to exclude uteropathies and oestrogen-induced changes in the haemogram or blood chemistry. Compared to the surgical treatment, there is the chance of recrudescence.
卵巢囊肿在母犬中具有重要的临床意义。目前，卵巢子宫切除术被视为金标准，但关于该物种病因及激素治疗的信息匮乏。然而，几乎不存在非手术治疗的标准化方案。关于激素治疗成功的报道很少，且通常局限于个别病例报告。本研究的目的是确定在更大数量的母犬群体中，人绒毛膜促性腺激素（hCG）或促性腺激素释放激素类似物布舍瑞林的成功率。
共有30只患有卵巢囊肿的母犬接受治疗，每只犬最多尝试三种不同的hCG和/或布舍瑞林治疗方案。
激素治疗在63%的治疗病例中取得成功。基于hCG和布舍瑞林的治疗方案成功率之间无显著差异。首次尝试治疗的成功率为40%，第二次和第三次治疗的成功率分别为33%和67%。保守治疗在首次治疗尝试中有2例失败，第二次治疗后有7例失败，第三次尝试后有1只母犬失败。在这10例病例中，进行了卵巢子宫切除术。
母犬卵巢囊肿的激素治疗为当前卵巢子宫切除术的金标准提供了一种可接受的替代方法，特别是可避免去势的负面副作用。然而，保守治疗需要在干预前进行健康检查，以排除子宫疾病以及雌激素引起的血常规或血液生化变化。与手术治疗相比，存在复发的可能性。
