[冷损伤所致脑损伤的特征及药理作用]
[Characterization and pharmacological effect on brain damage as a result of cold injury].
作者信息
Funk K F, Rudolph E, Blaschke M, Fischer H D
机构信息
Institut für Pharmakologie und Toxikologie, Medizinische Akademie Carl Gustav Carus Dresden.
出版信息
Biomed Biochim Acta. 1990;49(1):91-5.
PMID:2360912
Abstract
Freezing lesion of brain damages the blood-brain-barrier and induces edema. Both injuries are partially separate processes with different progress and diverse response to pharmacological treatment. A very weak lesion fails in to induce edema despite of an enhanced permeation of Evans blue. The injured permeability responds to treatment with dexamethasone or piracetam whereas the edema does not.
摘要
脑部冷冻损伤会破坏血脑屏障并引发水肿。这两种损伤在一定程度上是相互独立的过程，具有不同的进展情况以及对药物治疗的不同反应。尽管伊文思蓝的渗透增强，但非常轻微的损伤并不会引发水肿。损伤后的通透性对用地塞米松或吡拉西坦治疗有反应，而水肿则无反应。
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