Burrows Raquel, Atalah Eduardo, Leiva Laura, Rojas Pamela, Maza María Pía de la, Vásquez Fabian, Lera Lydia, Díaz Erick
Instituto de Nutrición y Tecnología de los Alimentos (INTA), Departamento de Nutrición y Escuela de Nutrición y Dietética y de la Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Arch Latinoam Nutr. 2012 Jun;62(2):155-60.
Family history (FH+) of non transmisible chronic diseases (NTCD) increase MetS risk. In Chile, the MetS affects 27% of overweight children, and fasting hyperglycemia is very low prevalent (4,0%). The objective was to study the prevalence of MetS and the cardiovascular risk factors (CVRF) in overweight children with a family background of NTCD and analyze its association with the number of relatives witth NTCD and with parental history (PH). In 183 overweight children (BMI > or = p85) mean age 11,8 +/- 1,8 (86 males) with a FH+ (parental or grandparental) of NTCD, were assessed the BMI z (CDC / NCHS), waist circumference, blood arterial pressure, fasting Glucose and Insulin (RIA), triglycerides, HDL chol. The MetS and the CVRF were diagnosed using the Cook phenotype and the insulin resistance (IR) through the HOMA-IR. Chi2, ANOVA, t Student and Willcoxon test were performed. The frequency of FH+ of DM2, hypertension and dyslipidemia were 81,4%, 88,0% and 71,6 % respectively. The MeTS prevalence was 46,5 % associated to overweight magnitude an parental history of NTCD. The prevalence of hypertriglyceridemia was 54,6%, while fasting hyperglycemia affected 31,4% of the sample. There was no association between number of relatives with NTCD and CV risk profile. We conclude that in overweight children with FH+ of NTCD, the prevalence of MetS, dyslipidemia and fasting hyperglycemia are significantly higher, than those observed in the general population of obese children.
非传染性慢性病（NTCD）的家族史（FH+）会增加代谢综合征（MetS）风险。在智利，MetS影响27%的超重儿童，空腹血糖异常的患病率很低（4.0%）。目的是研究有NTCD家族背景的超重儿童中MetS和心血管危险因素（CVRF）的患病率，并分析其与患NTCD亲属数量及父母病史（PH）的关联。对183名超重儿童（BMI≥p85）进行评估，这些儿童平均年龄11.8±1.8岁（86名男性），有NTCD的FH+（父母或祖父母），测量其BMI z值（疾病控制与预防中心/国家卫生统计中心标准）、腰围、动脉血压、空腹血糖和胰岛素（放射免疫分析法）、甘油三酯、高密度脂蛋白胆固醇。采用库克表型诊断MetS和CVRF，并通过稳态模型评估法（HOMA-IR）评估胰岛素抵抗（IR）。进行卡方检验、方差分析、t检验和威尔科克森检验。2型糖尿病、高血压和血脂异常的FH+频率分别为81.4%、88.0%和71.6%。MetS患病率为46.5%，与超重程度及NTCD的父母病史有关。高甘油三酯血症患病率为54.6% , 而空腹血糖异常影响了31.4%的样本。患NTCD的亲属数量与心血管风险状况之间无关联。我们得出结论，在有NTCD的FH+的超重儿童中，MetS、血脂异常和空腹血糖异常患病率显著高于肥胖儿童总体人群中观察到的患病率。
