Boyadzhieva M
Akush Ginekol (Sofiia). 2012;51(7):4-8.
The risk of developing type 2 diabetes and cardiovascular disease in women who had previously been diagnosed with gestational diabetes (GDM) is well established. A growing body of literature suggests that chronic disease has much of its origins in the fetal response to the intrauterine environment, a concept known as "fetal programming". Longitudinal studies have demonstrated that higher rates of obesity impaired glucose tolerance, hypertension, and dyslipidemia are evident in the offspring of diabetic women. Furthermore, distinct differences in regional populations, lack of routine screening and treatment of GDM worldwide, and long follow-up periods for offspring represent a challenge in assessing the risk for development of these abnormalities in the offspring of women who have had GDM.
先前被诊断为妊娠期糖尿病(GDM)的女性患2型糖尿病和心血管疾病的风险已得到充分证实。越来越多的文献表明,慢性疾病很大程度上起源于胎儿对子宫内环境的反应,这一概念被称为“胎儿编程”。纵向研究表明,糖尿病女性的后代中肥胖、糖耐量受损、高血压和血脂异常的发生率明显更高。此外,不同地区人群存在显著差异、全球范围内缺乏对GDM的常规筛查和治疗,以及对后代的长期随访,这些都给评估患有GDM的女性后代发生这些异常情况的风险带来了挑战。