Vodstrcil Lenka A, Hocking Jane, Read Tim R H, Grulich Andrew E, Fairley Christopher K
Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Australia.
Sex Health. 2013 Jul;10(3):220-3. doi: 10.1071/SH12184.
Anal cancer is more common in men who have sex with men with HIV. We aimed to determine if there was an association between anal squamous cell carcinoma (SCC) and HIV notifications in men in Victoria, Australia, at a population level.
We calculated the male age-standardised incidence rates for anal SCC, brain cancer and colon cancer for each local government area (LGA) in Victoria from 1982 to 31 December 2010 using the Victorian Cancer Registry. Male HIV rates in each LGA were calculated using the Victorian HIV Registry.
There were 288 men diagnosed with anal SCC, 8793 with brain cancer and 23?938 with colon cancer in 57 LGAs. There were 3163 men notified with HIV during the same period in the same LGAs (range: 4-435 per LGA). There was a significant positive correlation (r=0.45, P<0.001, r(2)=0.20) between the age-standardised rate of anal SCC and the rate of HIV notifications in men in each LGA but no correlation between the male age-standardised rate of colon (Pearson's r=-0.11, P=0.40) or brain (r=-0.05, P=0.71) cancers, and the rate of HIV. The rate of anal cancer was ~50% higher in LGAs with the highest HIV notification rate (incidence rate ratio=1.47; 95% confidence interval: 1.10-1.97).
At a population level, about one in five cases (r(2)=0.20) of anal SCCs in men are explained by the rate of HIV notifications in that LGA.
肛门癌在感染艾滋病毒的男同性恋者中更为常见。我们旨在确定在澳大利亚维多利亚州的男性群体中，肛门鳞状细胞癌（SCC）与艾滋病毒报告病例之间是否存在关联。
我们利用维多利亚癌症登记处的数据，计算了1982年至2010年12月31日期间维多利亚州每个地方政府区域（LGA）男性肛门SCC、脑癌和结肠癌的年龄标准化发病率。每个LGA的男性艾滋病毒感染率则通过维多利亚艾滋病毒登记处的数据进行计算。
在57个LGA中，有288名男性被诊断为肛门SCC，8793名患有脑癌，23938名患有结肠癌。同期，在相同的LGA中有3163名男性报告感染艾滋病毒（范围：每个LGA为4至435例）。每个LGA中男性肛门SCC的年龄标准化发病率与艾滋病毒报告率之间存在显著正相关（r = 0.45，P < 0.001，r² = 0.20），但男性结肠癌（皮尔逊r = -0.11，P = 0.40）或脑癌（r = -0.05，P = 0.71）的年龄标准化发病率与艾滋病毒感染率之间无相关性。艾滋病毒报告率最高的LGA中，肛门癌发病率高出约50%（发病率比值 = 1.47；95%置信区间：1.10 - 1.97）。
在群体层面，男性肛门SCC病例中约五分之一（r² = 0.20）可由该LGA中的艾滋病毒报告率来解释。
