Clin Chem Lab Med. 2013 Sep;51(9):1707-17. doi: 10.1515/cclm-2013-0136.
The rapid evolution of molecular biology techniques has a significant impact on laboratory medicine. Nowadays a large number of diagnostic tools are available to diagnose and to characterize the different phases of hepatitis B virus (HBV) infection. The advent of the assay for nucleic acid amplification and detection enables clinicians to initiate and monitor antiviral therapy whilst allowing basic scientists to carry out studies on HBV biology. This review will focus on the evolution of the diagnostic tools to detect and monitor HBV infection.
分子生物学技术的快速发展对实验室医学产生了重大影响。如今，有大量的诊断工具可用于诊断和描述乙型肝炎病毒（HBV）感染的不同阶段。核酸扩增和检测方法的出现使临床医生能够在开始和监测抗病毒治疗的同时，让基础科学家开展 HBV 生物学研究。本文综述将重点介绍检测和监测 HBV 感染的诊断工具的演变。
