Manlio Vinciguerra, Institute for Liver and Digestive Health, Division of Medicine, University College London (UCL), London SW7 2AZ, United Kingdom.
World J Gastroenterol. 2013 Dec 21;19(47):8902-9. doi: 10.3748/wjg.v19.i47.8902.
Many aspects of cellular physiology display circadian (approximately 24-h) rhythms. Dysfunction of the circadian clock molecular circuitry is associated with human health derangements, including neurodegeneration, increased risk of cancer, cardiovascular diseases and the metabolic syndrome. Viruses triggering hepatitis depend tightly on the host cell synthesis machinery for their own replication, survival and spreading. Recent evidences support a link between the circadian clock circuitry and viruses' biological cycle within host cells. Currently, in vitro models for chronobiological studies of cells infected with viruses need to be implemented. The establishment of such in vitro models would be helpful to better understand the link between the clock gene machinery and viral replication/viral persistence in order to develop specifically targeted therapeutic regimens. Here we review the recent literature dealing with the interplay between hepatitis B and C viruses and clock genes.
许多细胞生理过程都呈现出近似 24 小时的昼夜节律。昼夜节律钟分子机制的功能障碍与人类健康失调有关，包括神经退行性疾病、癌症风险增加、心血管疾病和代谢综合征。引发肝炎的病毒对宿主细胞的合成机制有严格的依赖性，以进行自身复制、存活和传播。最近的证据支持昼夜节律钟电路与病毒在宿主细胞内的生物周期之间存在联系。目前，需要建立用于研究感染病毒的细胞的生物钟的体外模型。建立这样的体外模型将有助于更好地理解时钟基因机制与病毒复制/病毒持续存在之间的联系，以便开发出有针对性的治疗方案。本文综述了关于乙型和丙型肝炎病毒与时钟基因相互作用的最新文献。
