Clin Chem Lab Med. 2013 Oct;51(10):1951-9. doi: 10.1515/cclm-2013-0146.
Several previous studies have demonstrated an association between habitual coffee intake and reduced risk of diabetes, cardiovascular morbidity and total mortality. Although the cause and effect relationship could not be determined through epidemiological data, antioxidant properties of coffee ingredients are presumed.
In the current study, by analyzing the data from 9877 subjects (mean age 59.2±10.4 years) who underwent general health screening, we evaluated the extent of in vivo oxidative stress by measuring derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP).
The mean levels of d-ROM and BAP were significantly lower in women than in men. By univariate analysis (ANOVA), coffee consumption showed a graded negative association with d-ROM value in men, but not in women. Coffee consumption was unrelated to BAP levels in men and women. Smoking was significantly associated with increased d-ROM and decreased BAP values in men. Multivariate-adjusted analysis showed that coffee intake of three or more cups per day was an independent negative correlate of d-ROM value in men. Sugar use was negatively associated with d-ROM and BAP values in women.
Among an essentially healthy population, coffee intake was negatively associated with d-ROMs in men, but not in women. Whether the favorable effect of coffee, if present, is related to lower oxidative stress levels needs further investigation.
几项先前的研究表明，习惯性饮用咖啡与降低糖尿病、心血管疾病发病率和全因死亡率的风险有关。尽管通过流行病学数据无法确定因果关系，但推测咖啡成分具有抗氧化特性。
在当前的研究中，通过分析 9877 名（平均年龄 59.2±10.4 岁）接受一般健康筛查的受试者的数据，我们通过测量活性氧代谢物（d-ROMs）和生物抗氧化潜力（BAP）的衍生值来评估体内氧化应激的程度。
女性的 d-ROM 和 BAP 平均值明显低于男性。通过单变量分析（ANOVA），男性的咖啡摄入量与 d-ROM 值呈负相关，但女性则不然。男性和女性的咖啡摄入量与 BAP 水平无关。吸烟与男性的 d-ROM 值升高和 BAP 值降低显著相关。多变量调整分析表明，每天饮用三杯或更多咖啡与男性的 d-ROM 值呈独立负相关。女性的糖摄入量与 d-ROM 和 BAP 值呈负相关。
在一个基本健康的人群中，咖啡摄入量与男性的 d-ROMs 呈负相关，但与女性无关。如果咖啡确实有有利影响，是否与较低的氧化应激水平有关，需要进一步研究。
