Ishizaka Yuko, Yamakado Minoru, Toda Akiko, Tani Mizuki, Ishizaka Nobukazu
Department of Cardiology, Osaka Medical College, 2-7 Daigakumachi, Takatsuki-shi, 569-8686 Osaka, Japan.
BMC Nephrol. 2013 Sep 9;14:191. doi: 10.1186/1471-2369-14-191.
In the general population, reported levels of oxidative stress and antioxidant potential seem to vary. The aim of this study was to investigate the levels of oxidant status markers in relation to estimated glomerular filtration rate (eGFR) and albuminuria in Japanese population.
Data were analyzed from 8335 individuals who underwent a general health screening test. For the estimation of albuminuria, urinary albumin-to-creatinine ratio (UAER) was calculated. Oxidant status was determined by assessing derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP).
After adjusting for age, high blood pressure, depressor agent use, CRP, smoking status, multivariate logistic regression analysis showed that the lowest eGFR quartile was associated negatively with the top d-ROM quartile in men (odds ratio 0.78 [95% CI 0.62-0.98, P = 0.034]) and the highest UAER was associated with the top d-ROM in men (odds ratio 1.68) [95% CI 1.35-2.10, P < 0.001]. In addition, both the first eGFR quartile and the fourth UAER quartile showed significant positive association with low BAP levels in men, but not in women.
Among men who underwent general health screening, lower eGFR and increased albuminuria was negatively and positively, respectively, associated with higher oxidative stress levels, whereas both conditions were positively associated with lower antioxidant potential levels.
在普通人群中，所报告的氧化应激水平和抗氧化潜力似乎有所不同。本研究的目的是调查日本人群中氧化状态标志物水平与估计肾小球滤过率（eGFR）和蛋白尿的关系。
对8335名接受一般健康筛查测试的个体的数据进行分析。为了评估蛋白尿，计算尿白蛋白与肌酐比值（UAER）。通过评估活性氧代谢产物衍生物（d-ROMs）和生物抗氧化潜力（BAP）来确定氧化状态。
在调整年龄、高血压、降压药使用、CRP、吸烟状况后，多因素逻辑回归分析显示，在男性中，最低的eGFR四分位数与最高的d-ROM四分位数呈负相关（比值比0.78 [95%可信区间0.62 - 0.98，P = 0.034]），最高的UAER与最高的d-ROM呈正相关（比值比1.68）[95%可信区间1.35 - 2.10，P < 0.001]。此外，男性中第一个eGFR四分位数和第四个UAER四分位数均与低BAP水平呈显著正相关，而女性中则无此关联。
在接受一般健康筛查的男性中，较低的eGFR和增加的蛋白尿分别与较高的氧化应激水平呈负相关和正相关，而这两种情况均与较低的抗氧化潜力水平呈正相关。
