DuBose Katrina D, McKune Andrew J
J Pediatr Endocrinol Metab. 2013;26(9-10):841-7. doi: 10.1515/jpem-2012-0415.
This study investigated the relation between salivary cortisol and the metabolic syndrome (MetSyn) score in young girls.
Twenty-three girls (8.4 ± 0.9 years) had a fasting blood draw to measure high-density lipoprotein (HDL), glucose, and triglyceride concentrations. Waist circumference and blood pressure were also measured. Saliva samples were collected three times (upon waking, 30 min post-waking, and in the evening) at home to measure cortisol levels. A continuous MetSyn score was created from blood pressure, waist circumference, HDL, triglyceride, and glucose values. Correlations examined the unadjusted associations between cortisol values, MetSyn score, and its related components. Regression analysis examined the relation between cortisol values, the MetSyn score, and its related components adjusting for breast development.
The MetSyn score was not related with cortisol values; however, HDL was negatively related with 30-min post-waking, evening, and area under the curve cortisol levels. Triglycerides were positively related to the 30-min post-waking and area under the curve values. These relations existed after adjusting for breast development.
While the MetSyn score was not related, specific MetSyn components were related to salivary cortisol levels. Cortisol may be involved in the development of some MetSyn components.
本研究调查了年轻女孩唾液皮质醇与代谢综合征（MetSyn）评分之间的关系。
23名女孩（8.4±0.9岁）进行空腹抽血，以测量高密度脂蛋白（HDL）、血糖和甘油三酯浓度。还测量了腰围和血压。在家中采集三次唾液样本（醒来时、醒来后30分钟和晚上）以测量皮质醇水平。根据血压、腰围、HDL、甘油三酯和血糖值创建连续的MetSyn评分。相关性分析考察了皮质醇值、MetSyn评分及其相关成分之间未经调整的关联。回归分析考察了皮质醇值、MetSyn评分及其相关成分之间的关系，并对乳房发育进行了校正。
MetSyn评分与皮质醇值无关；然而，HDL与醒来后30分钟、晚上以及曲线下面积的皮质醇水平呈负相关。甘油三酯与醒来后30分钟和曲线下面积值呈正相关。在对乳房发育进行校正后，这些关系依然存在。
虽然MetSyn评分无关，但特定的MetSyn成分与唾液皮质醇水平有关。皮质醇可能参与了某些MetSyn成分的发展。
